Creutzfeldt-Jakob disease (CJD) is a rare degenerative disease of the central nervous system with many similarities to Alzheimer's disease (Table 1). Recent advances in molecular biology have identified the molecular pathology of the disease, consisting of accumulation of "prion protein". ...
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Abnormal isoform of prion protein accumulates in the synaptic structures in patients with Creutzfeldt-Jakob disease A new method, which enabled the first immunohistochemical documentation of abnormal prion protein (PrP) in all patients with Creutzfeldt-Jakob disease (CJD... KITAMOTO,T. - 《American ...
Is Creutzfeldt-Jakob disease transmitted in blood? Creutzfeldt-Jakob disease (CJD) has been considered infectious since the mid-1960s, but its transmissibility through the transfusion of blood or blood prod... MN Ricketts,NR Cashman,EE Stratton,... - 《Emerging Infectious Diseases》 被引量: 168...
Alzheimer’s disease ADAM: A disintegrin and metalloproteinase AIDS: Acquired immunodeficiency syndrome APP: Amyloid precursor protein BSA: Bovine serum albumin BSE: Bovine spongiform encephalopathy CAA: Cerebral amyloid angiopathy CJD: Creutzfeldt–Jakob disease cKO: Conditional knockout CNS: ...
Small circular DNAs of 1.8 and 2.4?kb were initially discovered in highly infectious Creutzfeldt‐Jakob Disease (CJD) and scrapie particles from mammalian brain and cultured cells. Surprisingly, these protected cytoplasmic "SPHINX" DNAs contained replication (REP) initiation sequences resembling those ...
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Creutzfeldt-Jakob disease (CJD) in humans, is the conversion of the normal or cellular prion protein (PrPC) into the abnormal or scrapie isoform (PrPSc... Zou,W.-Q. - 《Journal of Biological Chemistry》 被引量: 270发表: 2003年 Molecular Genetics of Transmissible Spongiform Encephalopathies ...
JB Aitken,CJD Austin,NH Hunt,... - 《Biochemical & Biophysical Research Communications》 被引量: 3发表: 2014年 The management of Graves' disease in New Zealand 2014 BACKGROUND: Treatment options for Graves' disease (GD), namely anti-thyroid drugs (ATD), surgery or radioiodine (RAI), have...