BackgroundCurrent cervical cancer screening guidelines recommend a 1-year follow-up period for patients with a postmenopausal low-grade squamous intraepithelial lesion (LSIL) who are test negative for high-risk human papillomavirus (HrHPV). The aim of this study was to assess whether such patients ...
Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We s
AURKA is an essential kinase, as the corresponding knock-out mice die before the 16-cell stage. In addition, germ line AURKA deficiency causes embryonic death at the blastocyst stage. AURKA also regulates meiotic maturation and fertilization of mouse oocytes [30]. AURKA is expressed in all somat...
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Ozturk M,Umudum H,Alanbay I,et al.Risk of HSIL(CIN2-3)on colposcopic biopsy is minimal in postmenopausal women with LSIL on cytology and a negative HRHPV test[J].Diagn Cytopathol,2016,44(12):969.Risk of HSIL (CIN 2-3)on colposcopic biopsy is minimal in postmenopausal women with ...
All prostatectomy specimens were completely embedded and were reviewed to establish stage and grade of the respective prostate cancers. For the construction of our cohort, prostate tissue blocks that contained large areas of prostate cancer and normal prostate parenchyma were selected. Gleason sums were...
Advanced stage is the most important prognostic factor for survival in patients with systemic acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma treated with CHOP and highly active antiretroviral therapy. Int J Hematol. 2007;86(4):337-42....
We dissected mutant embryos at various gestational days to determine the embryonic stage of lethality. We obtained both Brca2LP/KO and Brca2LP/LP embryos in expected Mendelian ratios at 9.5dpc, 13.5dpc, and 14.5dpc (Table 2). The number of Brca2LP/KO embryos was significantly reduced at ...
What is a major predisposing factor to cervical cancer? How can a female get cervical cancer? What does stage 2b cervical cancer mean? What does stage 4 cervical cancer mean? What does stage 3 cervical cancer mean? How is HPV related to cervical cancer? What are the different stages of ce...
NCOA3 levels were observed to be dysregulated in different subtypes of breast cancer samples than in normal breast tissue (Figure 8a). An increase in tumour stage (log-rank; P = 0.009) and NCOA3 expression was associated with shorter overall survival (log-rank; P = 0.043). Prognostic ...