Chemo Is Praised for Hard-To-Treat Cancer
The National Comprehensive Cancer Network said Wednesday that nearly all the centers it surveyed late last month were dealing with shortages of carboplatin and cisplatin, a pair of drugs used to treat a range of cancers. Some are no longer able to treat patients receiving carboplatin at the inten...
Chemotherapy is a medical treatment that is used to treat cancer using anti-cancer drugs. The drugs administered inhibit mitosis, or cell division of the cancer cells. One of the side affects is often hair loss, because the drugs usually also impact normal, healthy, fast-dividing cells, such...
Also known as adjuvant therapy, preventative chemotherapy is often used after surgery to reduce the chance of cancer coming back and spreading. Lawrence Young, professor of molecular oncology at the University of Warwick, explains: "Even after successful removal of all visible cancer by...
Some time goes by, and the patient has more tests only to find out that the cancer is back. And this time it’s spread to their liver, their lungs, their brain, their bones… They go through more rounds of chemo and radiation, but the treatments don’t work as well the second time...
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Ki-67 null cells had a proliferative disadvantage compared to wildtype controls in colony formation assays and displayed increased sensitivity to various chemotherapies. Ki-67 null cancer cells showed decreased and delayed tumor formation in xenograft assays, which was associated with a reduction in ...
4 lots of chemo followed by a scan highlighted that some of it had disappeared but unfortunately along with the positive feeling that it had partly worked, there were also new spots that were showing which meant that the treatment simply wasn’t strong or effective enough. The next step ...
Importantly, even in patients with initially platinum-sensitive recurrence (PSR), sensitivity to platinum-based chemotherapies decreases with each subsequent relapse and with the inevitable development of platinum-resistant disease [4]. Recently, there has been no optimal treatment regimen for these ...
GSDME is modified during anti-cancer drug-induced pyroptosis TNFα+CHX and navitoclax not only induced pyroptosis in HCT116 cells, but also in Hela cells and HeyA8 (Supplementary Figs. 3 and 4). The anti-cancer drugs induced GSDME cleavage was further investigated in these cells (Fig. 5a–...