) and carprofen (5 mg kg−1 s.c.) and placed in a stereotaxic frame (Angle Two, Leica Microsystems) on a heat mat (ThermoStar Homeothermic Monitoring System, RDW Life Science) at 36.5 °C. Mice were implanted with two miniature screw electrodes (+1.5 mm Bregma, +1.5 ...
Another 4–6 (for adults) or 2 (for peripubertal rats) anchor screws were attached to the skull. Electrodes and connectors (E363, Plastics One) were secured with dental cement to the anchor screws. Rats were housed individually after surgery, and received carprofen (5 mg/kg, i.p.) and ...
In addition, 0.01 ml Rimadyl (5 mg kg−1 Carprofen) analgesia was given subcutaneously (s.c.). Animals are implanted with an osmotic minipump (ALZET Model 2006; Charles River, Sulzfeld, Germany) into the back, administering β-CCE (1.5 mg kg−1 per day; s.c.) for ...
Carprofen was administered pre-operatively and again 24 hr later (2.5 mg/kg, s.c.). Food restriction was lifted prior to surgery and re-applied after recovery (7 days). Next, rats were given 2 instrumental and 2 Pavlovian reminder sessions identical to pre-surgical training. Bilateral ...
Rats received 5 mg/kg carprofen s.c. on the day of surgery and four days following, and 60 mg/kg p.o. cephalexin was administered for ten days following surgery to prevent infection. Electrodes were slowly advanced to final recording coordinates (∼4.8 mm from skull, matched to GRIN ...
In a specific embodiment, the term “pharmaceutically acceptable” means approved by a regulatory agency or other generally recognized pharmacopoeia for use in animals, and more particularly in humans. The term “carrier” refers to a diluent, adjuvant, excipient, or vehicle with which the ...
Buprenorphine (0.1 mg/kg sc), carprofen (5 mg/Kg sc) and lidocaine (4 mg/kg sc) was administered. The body temperature was maintained at 37 °C by a heating pad. An ocular ointment (Viscotears, Alcon) was applied over the eyes. The head of the mouse was fixed in a ...
In addition, 0.01 ml Rimadyl (5 mg kg − 1 Carprofen) analgesia was given subcutaneously (s.c.). Animals are implanted with an osmotic minipump (ALZET Model 2006; Charles River, Sulzfeld, Germany) into the back, administering β-CCE (1.5 mg kg − 1 per day; s.c.) for 42 days...
The animal was given a dose of carprofen to reduce postsurgical pain (s.c, 5 mg/kg) before the end of the surgery. Suturing the skin over the wound completed the surgery and the animal was then allowed to recover. Animals were sacrificed by transcardial perfusion 10–14 days after ...
For orthotopic tumor implantation, C57Bl/6NCrl female mice (subtotal n = 163) were anesthetized with isoflurane (1–3% vol.) and injected with carprofen (5 mg/kg, ScanVet) into the nape of the neck. The surgical field was sterilized with iodine and a ca. 1-cm-long incision was made...