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His initial compound, melarsen oxide, p-(4,6-diamino-s-triazinyl-2-yl) aminophenylarsenoxide, was complexed with dimercaptopropanol (British antilewisite) to form a less toxic complex, melarsoprol. Until 1990, it was the only agent available for curing late-stage (CNS) disease of East ...
Nephrotoxicity (acute and/or chronic): May occur due to LUPKYNIS or concomitant nephrotoxic drugs. Monitor renal function; consider dosage reduction. ( 5.3) Hypertension: May require antihypertensive therapy; monitor relevant drug interactions. ( 5.4) Neurotoxicity: Including risk of posterior rever...
Hepatic ER stress occurs upon excessive accumulation of unfolded and misfolded proteins in the ER or when ER calcium is depleted. Three main sensors trigger ER signalling cascades aimed to restore ER homeostasis15(Fig.2). A large number of studies have established that exposure to saturated FFAs ...
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hydrogen perox- ide; HO·, hydroxyl radical; NAC, N-acetylcysteine; NOX, NAD(P)H oxidase; ROS, reactive oxygen species; SOD, superoxide dismutase; O2·؊, superoxide 121 122 AUTEN AND DAVIS of the more toxic and reactive HO· in the presence of reduced transition metals such as iron. ...
Like oxygen or calcium, levodopa can be toxic in vitro when it is present in high concentrations or in the absence of glial cells. However, glial ... Agid,Y. - 《Neurology》 被引量: 265发表: 1998年 Toxic effect of metal ions on biochemical oxygen demand Toxic effect of metal ions lik...
sulphides is a major source of air pollution and the main drawback of this process is that it releases a large amount of metallic as well as toxic and acidic compounds which cause harm to the environment. an example of roasting is when zinc sulphide is converted into zinc oxide. 2zns+3...
neuronal nitric oxide synthaseventricularcontractioncalciumAlthough pharmacologic therapy has made impressive advances in the past decade and is the mainstay of therapy for heart failure (HF), there is still a large unmet need, because morbidity and mortality remain unacceptably high. Implanted medical ...
to the sites of entry of many parasites. These sites include the lymphoid tissue of the respiratory tract, the gastrointestinal tract, and the skin. Eosinophils, cells that migrate to the site of antigen introduction in anaphylaxis, elaborate mediators that are toxic to the outer parasitic ...