beta-Lapachone (beta-Lap) triggers apoptosis in a number of human breast and prostate cancer cell lines through a unique apoptotic pathway that is dependent upon NQO1, a two-electron reductase. Downstream signaling pathway(s) that initiate apoptosis following treatment with beta-Lap have not been...
1991. A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule. J. Biol. Chem. 266:309-315.Turbide C, Rojas M, Stanners CP, Beauchemin N: A mouse carcino- embryonic antigen gene family member is a calcium-dependent cell adhesion molecule. J Biol ...
DE pathway analysis (Supplementary Table 3) revealed the enrichment of KEGG pathways related to calcium and cAMP signaling, synaptic function and long-term potentiation in astrocyte subcluster 1 (Extended Data Fig. 7c), suggesting that this subcluster is associated with supporting synaptic function....
calcium channel resistosome NLR plant immunity cell death disease resistance Arabidopsis Xanthomonas Pseudomonas single-molecule imaging Introduction The plant innate immune system is composed of cell surface receptors, which perceive immunogenic molecular patterns derived from invading pathogens, and intracellula...
AlphaFold-predicted structure of theRuminococcus gnavusBilR with sequences coloured to show their degree of conservation within clade 1 based on a ConSurf conservation analysis. A docked bilirubin (green) and FMN (orange) molecule are shown on the structure, and the insets show the potential site...
anti- ADCY8 antibody规 格 0.2ml/200μg 1ml/1mgThis is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence(By similarity).adenylate cyclase 8(brain) anti- Adenosine A1 Receptor antibody抗体来源 RabbitADORA1, also named as RDC...
This is due to the extra amount of energy supplied by the kinetic energy of molecules that helps overcome the lattice energy and breaks the inter-atomic bonds in the molecule. The solubility of calcium carbonate in pure water is very low, almost 0.013 g/L at 25 °C. ...
2f). Prioritizing these gene targets based firstly on those that showed significant differential gene expression (>5-fold change) and secondly on the availability of small molecule inhibitors/drugs, led to identification of KCNMA1. This gene encodes the calcium-activated potassium channel subunit ...
a four-parameter model, equation (1). pCa = −log([free Ca2+]) control ATPase activity = 0.26 µM s−1.c, Selective inhibition of bovine cardiac and slow skeletal versus rabbit fast skeletal myofibril ATPase activity by aficamten. Myofibrils were tested at a calcium ...
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting compounds, which have multiple targets on a single pathogen, offer an effective approach to combat drug-resistant pathogens, although ensuring potent activity and high selectivity remains a challenge. Here we prop...