On the contrary, mTORC1 inhibition by rapamycin had no effect on the METTL3-GLUT1 axis (Supplementary Figure 7B). In GLUT1-deficient CRC cells, shMETTL3 was incapable of affecting mTORC1 signaling (Figure 6E), implying that METTL3 promotes mTORC1 signaling via GLUT1. To confirm these ...
Human protein atlas (HPA) and protein interaction analysis Immunofluorescent staining figures of ALKBH5 in U251 GBM cell line and the immunohistochemical staining data of glioma samples with low- and high grade were obtained from the Human Protein Atlas (HPA, https://www.proteinatlas.org/19. ...
31. However, recent evidence indicates that mTORC1 activity, as measured by the phosphorylation status of its downstream targets S6 kinase or S6, increases in old skeletal muscle13,14,15,16,17,18. So far, our data clearly demonstrate that systemic rapamycin administration attenuates...
An atlas of cell types in normal peritendinous and injured tissue was established by first clustering nuclei at a coarse level and then annotating each cluster with cell type-specific markers (Fig.1c). We identified eight major cell clusters including mononuclear phagocytes (MPs,n = 16 29...
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In summary, our human iPSC-based multi-tissue MPS faithfully recapitulates the WAT-liver axis allowing for modeling of obesity-induced disorders and analysis of tissue-specific effects of obesity-targeting drugs. Our model provides an authentic and scalable in vitro approach to advancing the understand...
Laminectomy of the atlas and sometimes of the axis must often be done. The dural incision is centered on the dural ring surrounding the vertebral artery. Opening the dural ring leaves a dural cuff of sufficient size around the artery. An incision along the sigmoid sinus is extended inferiorly...
To access comprehensive data on GTEx, GDC and TCGA Pan-Cancer normalized gene expression, phenotypic information, and somatic mutations, we utilized XenaBrowser [55] to extract publicly available data from The Cancer Genome Atlas (TCGA) (https://www.cancer.gov/tcga). The combined cohort of TCGA...
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 2004, 101, 6062–6067. [CrossRef] [PubMed] 11. Temelkova-Kurktschiev, T.; Hanefeld, M.; Chinetti, G.; Zawadzki, C.; Haulon, S.; Kubaszek, A.; Koehler, C.; Leonhardt, W.; Sta...
Number of days difference between the start of the summer-regime period and the spring snow-free date (left panel,x-axis) as well as between the end of the summer-regime period and the autumn snow-onset date (right panel,x-axis). The summer-regime timings are derived from the smoothed ...