SpringerPlus 2012, 1:83 http://www.springerplus.com/content/1/1/83 a SpringerOpen Journal REVIEW Open Access Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? – a systematic review Lawal AbdulRazzaq Oluwagbemiga1*, Atoyebi Oluwole1 and...
Telomeres BRCA2 Genetic Instability Telomere Erosion Telomere Fragility Introduction The inheritance of one mutant allele of BRCA2 predisposes carriers to early onset breast cancer through loss of heterozygosity; thus, BRCA2 is a tumor suppressor (1, 2). Recently, it has been shown that BRCA2 hete...
ALCOHOL DEHYDROGENASE-1B REPRESSES THE PROLIFERATION, INVASION AND MIGRATION OF BREAST CANCER CELLS BY INACTIVATING THE MITOGEN-ACTIVATED PROTEIN KINASE SI... Breast cancer (BRCA) is a serious life-threatening cancer, especially triple-negative breast cancer (TNBC). Alcohol dehydrogenase-1B (ADH1B) ...
to be proactive about my health, I underwent a genetic test that looks for 90 different cancer genes. I tested negative for everything, including BRCA [the most well-known breast cancer gene]. My sister Sara had also tested negative. We called each ot...
HR stands for hormone receptor, and HER2 stands for human epidermal growth factor receptor 2. Learn about the difference between these types of breast cancer.
Mutations in tumor suppressor genes such as BRCA1, BRCA2, the PI3K/AKT/mTOR pathway, and PTEN can be related to the formation of multicentric breast cancer. Multicentric breast cancer can be diagnosed through mammography, histopathology, and genetic testing. Furthermore, treatment options for mu...
Breast cancer suscept- ibility loci have been shown to be enriched for FOXA1-binding sites at active regulatory elements in breast cancer cells; and the 2q35 locus contains variants predicted to modulate the affinity of FOXA1 (ref. 4). FOXA1 is a pioneer factor and master regulator of ER...
With the discovery of the BRCA1 gene and other genetic mutations associated with breast cancer, it has been established that hereditary mutations account for up to 5% of patients presenting with breast cancer.We performed a systematic review of English Language Literature to determine the role of ...
[36]. In addition, AURKA can interact with several tumor suppressor proteins (e.g. p53, BRCA1, Chfr) and inhibit their activities and/or expression, leading to tumor progression. AURKA overexpression also results in SMAD5 phosphorylation and its subsequent nuclear translocation, causing SOX2 up...
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been