Is BRCA1 associated with familial breast cancer in India?BRCA1breast cancerCSGEPCRmutationcancer predispositionNo Abstract Availabledoi:10.4161/cbt.1.1.34CouchFergus J.Taylor & FrancisCancer Biology & Therapy
ALCOHOL DEHYDROGENASE-1B REPRESSES THE PROLIFERATION, INVASION AND MIGRATION OF BREAST CANCER CELLS BY INACTIVATING THE MITOGEN-ACTIVATED PROTEIN KINASE SI... Breast cancer (BRCA) is a serious life-threatening cancer, especially triple-negative breast cancer (TNBC). Alcohol dehydrogenase-1B (ADH1B) ...
BRCA2prognosiswild type allele lossadjuvant treatmentOverexpression of the Aurora A kinase has been shown to have prognostic value in breast cancer. Previously, we showed a significant association betweenAURKAgene amplification andBRCA2mutation in breast cancer. The aim of this study was to assess ...
SpringerPlus 2012, 1:83 http://www.springerplus.com/content/1/1/83 a SpringerOpen Journal REVIEW Open Access Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? – a systematic review Lawal AbdulRazzaq Oluwagbemiga1*, Atoyebi Oluwole1 and...
With the discovery of the BRCA1 gene and other genetic mutations associated with breast cancer, it has been established that hereditary mutations account for up to 5% of patients presenting with breast cancer.We performed a systematic review of English Language Literature to determine the role of ...
The largest lesion in the surgery group was up to 7 cm in diameter. The surgery group had 8 (40.0%) and 6 (30.0%) patients with known breast cancer (BRCA) status and homologous recombination deficiency (HRD) status, respectively, while the chemotherapy group had 12 (38.7%) and 6 (19.4...
Telomeres BRCA2 Genetic Instability Telomere Erosion Telomere Fragility Introduction The inheritance of one mutant allele of BRCA2 predisposes carriers to early onset breast cancer through loss of heterozygosity; thus, BRCA2 is a tumor suppressor (1, 2). Recently, it has been shown that BRCA2 hete...
Mutations in tumor suppressor genes such as BRCA1, BRCA2, the PI3K/AKT/mTOR pathway, and PTEN can be related to the formation of multicentric breast cancer. Multicentric breast cancer can be diagnosed through mammography, histopathology, and genetic testing. Furthermore, treatment options for mu...
. I tested negative for everything, including BRCA [the most well-known breast cancer gene]. My sister Sara had also tested negative. We called each other and high-fived on the phone. That same winter, I had a normal mammography. Two months later,...
of the city centre.My mother fought breast cancer for almost a decade and died at 56. My children never have the chance to know her and experience how loving and gracious she was. We often speak of “Mommy's mommy”, and 省略... 1、Angelina Jolie carries a “faulty” gene, BRCA1,...