The histone-like nucleoid structuring (H-NS) protein is a DNA binding factor, found in gammaproteobacteria, with functional equivalents in diverse microbes. Universally, such proteins are understood to silence transcription of horizontally acquired genes
Darapladib was originally developed as a selective inhibitor of extracellular lipoprotein-associated PLA2 (Lp-PLA2) (Blackie et al., 2003). However, Lp-PLA2 is absent in RBCs and is also not internalized by P. falciparum-infected RBCs from ...
pseudomallei samples from the northeast Thailand collection were cultured on Ashdown, selective agar plates and confirmed the species using latex agglutination test and matrix-laser absorption ionisation mass spectrometry (MALDI-TOF MS). A single colony from Ashdown agar plate was subjected to culture ...
Nodules may ulcerate and drain small amounts of pus or blood-tinged fluid. The differential diagnosis should include the bacterial and fungal causes of lymphangitis (glanders, equine histoplasmosis, ulcerative lymphangitis) and sterile nodular panniculitis (q.v.). Diagnosis is made by cytology,...
The organism is relatively easy to culture on MacConkey's agar during early phases of infection, whereas the intestine may be free of aerobic bacteria during later stages. Citrobacter rodentium also can be detected by molecular hybridization (Schauer et al., 1995). Differential diagnosis. ...
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. PLoS ONE. 2012;7(6): e38658. Article CAS PubMed PubMed Central Google Scholar Diner I, Hales CM, Bishof I, Rabenold L, Duong DM, Yi H...
Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Breast Cancer Res. 2009;11(6):R88. Article Google Scholar Taylor SC, Laperriere G, Germain H. Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from...
In present study, we explored the function of AHSA1 in MM cell proliferation and PI resistance, revealed the mechanism on how Bufalin targeted AHSA1 to suppress MM development, and identified the potential therapeutic effects of KU-177 as a selective AHSA1 inhibitor [23]. ...
Intact sacculi (untreated), sacculi subjected to mild acid hydrolysis (mild acid), or deamination with HONO (HONO) were incubated with GFP-AtlAEfs, and examined by fluorescence microscopy (GFP-AtlAEfs, top panels) and differential interference contrast (DIC, middle panels). An overlay of fluore...
To test the metabolic functions of BMAT in vivo we first used18F-FDG PET/CT in mice to determine if, like WAT, BMAT is insulin-responsive. As expected, insulin decreased blood glucose (Fig.3a) and increased18F-FDG uptake in the heart, iWAT, gWAT and skeletal muscle (Fig.3b, c, e)....