The histone-like nucleoid structuring (H-NS) protein is a DNA binding factor, found in gammaproteobacteria, with functional equivalents in diverse microbes. Universally, such proteins are understood to silence transcription of horizontally acquired genes
We retrieved microarray data from GEO using the R package GEOquery78 v.2.58.0, and differential gene expression analysis was performed using the R package limma79 v.3.58.1. We used binary expression patterns reported in Ooi et al. 47 to compare the expression profiles of lineage-specific ...
Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Breast Cancer Res. 2009;11(6):R88. Article Google Scholar Taylor SC, Laperriere G, Germain H. Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from...
116 The recognition of T cell heterogeneity based on expression of tissue-selective homing receptors suggests that an individual's propensity for specific allergic disease may be a function of end-organ targeting by effector T cells. In this respect, T cells migrating to the skin express CLA, ...
Darapladib was originally developed as a selective inhibitor of extracellular lipoprotein-associated PLA2 (Lp-PLA2) (Blackie et al., 2003). However, Lp-PLA2 is absent in RBCs and is also not internalized by P. falciparum-infected RBCs from ...
In present study, we explored the function of AHSA1 in MM cell proliferation and PI resistance, revealed the mechanism on how Bufalin targeted AHSA1 to suppress MM development, and identified the potential therapeutic effects of KU-177 as a selective AHSA1 inhibitor [23]. ...
Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer’s disease (AD) brain and cerebrospinal fluid (CSF). However, it remains challenging to detect these proteins in plasma using standard mass spectr...
Importantly, like Kuramochi, RMG1 showed differential sensitivity to PARGi and PARPi. However, while OVMANA were more sensitive to PARGi than PARPi, the distinction was less clear-cut. These observations indicate that PARG inhibitors may open up new opportunities to treat ovarian cancers. However...
2c. This selective cleavage has been utilized successfully to release the L. plantarum WTA from peptidoglycan20. Nitrite is rapidly protonated to form HONO in acidic conditions23. We observed that incubation of isolated cell wall material and intact sacculi with acidified nitrite released 70–80% ...
In 1969, de Duve and colleagues1 postulated that the release of these enzymes from the lysosomes would jeopardize cellular integrity. Although a series of subsequent studies clearly linked lysosomal rupture to necrotic cell death, Firestone and colleagues2,3 reported that the induction of selective ...