The complexity of the nervous system is not only defined by intricate neuronal networks but is also reflected by the cellular diversity of the different glial cells found throughout the nervous system. The number of functions attributed to the different glial cells is steadily growing and ranges fr...
While traveling abroad, 5G users will seamlessly enjoy a5G roamingexperience on visited networks. A fallback to 3G-4G will be guaranteed. How will 5G boost the commercialization of IoT devices relying on cellular rather than Wi-Fi technology? Wi-Fi wireless is a "Local Area Network" technology...
Ecotype (cellular community) discovery: Ecotypes or cellular communities are derived by identifying patterns of co-occurrence of cell states across samples. First, EcoTyper leverages the Jaccard index to quantify the degree of overlap between each pair of cell states across samples in the discovery ...
Through the earlier work on genetic circuits5,6,7 in bacteria and the more recent advances in tunable8 and precisely edited9 logical expression systems, we can picture a future of cellular devices that take advantage of complex bacterial and mammalian10 genomes. Another biocomputing system, in ...
To test this possibility, we first set up an in vitro system in which we can control the cellular levels of YY1 protein. Briefly, human YY1 was added into the mouse cell line Neuro2A, and used as an exogenous gene, which allows for easy distinction between the exogenous and endogenous YY...
Total cellular RNA was prepared by using the RNeasy Plus mini kit (Qiagen), and isolated RNA was subjected to DNase I (Invitrogen) treatment. cDNA was synthesized starting from 1 μg of total RNA according to the ImPromII reverse transcription kit (Promega) manual and used for qRT-PCR. Th...
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Studies of cellular mechano-signaling have often utilized static models that do not fully replicate the dynamics of living tissues. Here, we examine the time-dependent response of primary human mesenchymal stem cells (hMSCs) to cyclic tensile strain (CTS
10d,e), including 153 down- and 36 upregulated proteins (PC analyses of proteins provided in Fig. 8h). GO analysis of the 153 ERX-41-downregulated proteins revealed that three of the top five cellular processes were involved in ER protein maturation functions, such as protein folding...