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On the basis of the findings of these trials, the 2017 European Society of Cardiology guidelines recommend dual therapy with an oral anticoagulant after 1 month of triple therapy in patients with high bleeding risk, adding that direct oral anticoagulants may be considered in place of warfarin [...
Continuous anticoagulant use 2.75 0.60-12.53 .192 Continuous ACE inhibitor use 1.71 0.48-6.10 .411 Aortic-related reintervention Age 0.65 0.32-1.33 .238 Male sex 1.13 0.74-1.73 .569 Continuous beta-blocker use 1.05 0.62-1.78 .844 Maximal preoperative aortic diameter 1.03 1.02-1.05 < .001 Race...
Sulu B, Aytac E, Stocchi L, Vogel JD, Kiran RP. The minimally invasive approach is associated with reduced perioperative thromboembolic and bleeding complications for patients receiving preoperative chronic oral anticoagulant therapy who undergo colorectal surgery. Surg Endosc. 2013; 27(4):1339-45....
Not taking an oral anticoagulant, or if so, the dose and type should be considered using established criteria when deciding on emergency thrombolytic therapy. If a stroke patient has takenheparinwithin the last 48 hours, they need special considerations for thrombolytic therapy. ...
The treatment is easy to take and cheap and occurs in short treatment regimens, considered to be safe. As a result they are widely prescribed, often as part of an immunomodulating package that includes other interventions such as aspirin or low molecular weight heparin (LMWH). But do they ...
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identify a stereospecific small molecule (ERX-41)
Patients who develop stroke while being on OAC should also be considered for LAAC. But, caution must be executed while interpreting the current evidence as these devices may only offer benefit in decreasing LAA-dependent cardio-embolic stroke and non-LAA-dependent thrombi contribute to a small ...
In the present study, control subjects were considered free from CAD or thrombosis, and they received no antiplatelet therapy. Because all CAD patients had already received antiplatelet therapy by their attending physicians when they first visited our hospital, plasma samples from CAD patients without ...
Peptides having at least 95% confidence with multiple modified and cleaved states of the same underlying peptide sequence were considered distinct. Multiple spectra of the same peptide due to replicate acquisition or different charge states were counted once. Inclusion criteria required detection of ≥...