Protein-denaturantAmino acid solubilityTransfer free energyPreferential interactionArginine is a useful solvent additive for many applications, including refolding and solubilization of proteins from insoluble pellets, and suppression of protein aggregation and non-specific adsorption during formulation and ...
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. Transcriptional induction by interferons requires the tyrosine and serine phosphorylation of the STAT1 transcription factor as well as its amino-terminal a... W Zhu,T Mustelin,M David - 《Journal of ...
Molecular dynamics simulations on the Tre 1 G protein-coupled receptor : Exploring the role of the arginine of the NRY motif in Tre 1 structure Background: The arginine of the D/E/NRY motif in Rhodopsin family G protein-coupled receptors (GPCRs) is conserved in 96% of these proteins. In...
Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression a... 2017. Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA...
Fig. 1 Conformational change of polyglutamine proteins in the polyglutamine diseases and the effect of arginine as a protein conformation stabilizer. Credit: Brain Familial spinocerebellar ataxia (SCA), Huntington disease, and spinal and bulbar muscular atrophy are inherited neurodegenerative diseases. Becau...
Fig. 4: Arginine mediated nuclear retention of TEAD4. Full size image YAP1 (yes-associated protein 1) is the major effector of Hippo signaling pathway, which has been widely considered as a major coactivator of TEAD proteins. To evaluate whether arginine targets TEAD4 through YAP1 signaling pa...
First, to block NO production from NOS isoforms, isolated arteries were incubated with the NOS inhibitor L-nitroarginine methyl ester (L-NAME) before being subjected to Na2S2O4-induced hypoxia (Fig. 7e). NOS inhibition did not affect the robust dilation in the Hba1+/+, Hba1fl/fl, Hba1WT...
Autophagy is a conserved cellular process that degrades and recycles cytoplasmic components via a lysosomal pathway. The phosphatidylethanolamine (PE)-conjugation of the Atg8 protein plays an important role in the yeast autophagy process. In humans, six Atg8 homologs, including MAP1LC3A, MAP1LC3B, MA...
The protein arginine methyltransferase 5 (PRMT5) is an enzyme involved in growth and survival pathways promoting tumorigenesis. However, little is known about the biologic function of PRMT5 and its therapeutic potential in multiple myeloma (MM). In the present study, we identified and validated PR...
Further, prevention of NETosis by protein arginine deiminase (PAD) inhibition in mice significantly reduced mortality, tissue damage, and inflammation in mice induced with NEC. Our results suggest that the hyperinflammation observed in NEC is a NETs-dependent process, as NEC severity was significantly...