Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the 20 years since the concept of a proteolysis-targeting chimera (PROTAC) molecule...
Epidermolysis bullosa acquisita antigen, a new major component of cutaneous basement membrane, is a glycoprotein with collagenous domains. J Invest Dermatol 1986;86:668-72.Woodley DT, O'Keefe EJ, Reese MJ, Mechanic GL, Briggaman RA, Gammon WR (1986) Epidermolysis bullosa acquisita antigen, a ...
Autoreactive T cells specific for myelin antigens are thought to play a role in the pathogenesis of multiple sclerosis (MS). We compared T cell proliferative responses in peripheral blood following challenge in vitro with myelin/oligodendrocyte glycoprotein (recombinant protein, rMOG), myelin basic ...
The antigen was cell-associated except in the late phase of the infection, when a small amount (3.5 g per 106 cells) was released. The cell-associated antigen consisted of polypeptides of molecular mass 160 kDa and 175 kDa, comigrating with the authentic precursor S′ and the mature S ...
SARS-CoV-2 is a sarbecovirus with an overall structure similar to that of SARS-CoV-1. The SARS-CoV-2 genome contains the large 5′ open reading frame (ORF) 1ab encoding two polyproteins, including 16 nonstructural proteins (NSPs), namely NSP1–NSP16. The 3′ end of the genome encod...
LDLR binds directly to CCHFV glycoprotein Gc with high affinity, which supports virus attachment and internalization into host cells. Consistently, a soluble sLDLR–Fc fusion protein or anti-LDLR blocking antibodies impair CCHFV infection into various susceptible cells. Furthermore, genetic knockout of...
Functions of cell surface galectin-glycoprotein lattices Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or m... GA Rabinovich,MA Toscano,SS Jackson,... - 《Current Opinion in Structural Biology》 被引...
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and re... In addition, a polymorphism of PC-1 (K121Q) in various ethnic populations is closely associated with insulin resistance, T2D, and cardio [co...
Of these, we identified the plasma glycoprotein fetuin-A (Ahsg) as an evolutionary conserved HIF target gene, and further investigated its role in hypoxic fetal kidneys using fetuin-A KO mice. Beyond its recognized role as systemic calcification inhibitor, our findings establish fetuin-A as a ...
Antigen targeted therapy Hedgehog (Hh) signaling pathway Hh is a key pathway required for the survival of leukemia stem cells which can be disturbed by specific inhibitors. Glasdegib, an oral Hh pathway suppressor, has demonstrated a strong suppression effect on the proliferation of AML cells [18...