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In all, 3240 patients with AML were analyzed, and 36 (1.11%) were found to have CNS involvement at diagnosis. The incidence of CNS disease among the 5 studies with per protocol mandatory lumbar puncture (LP) was similar to the incidence among studies in which LP was performed at the ...
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Xeroderma pigmentosum (XP) which is characterized by similar photosensitive skin lesions and development of numerous malignancies on exposure of the skin to sun light is a rare hereditary disease casued by deficit of an ability to repair ultraviolet (UV)-induced damage of DNA. Re- cently Beigh...
The endothelium in the liver, kidney, spleen, and skeletal muscle together with circulating leukocytes appear to be the primary target cells (Al-Hussinee et al., 2011; Amlacher et al., 1980; Smail and Munro, 2012), and lytic parenchymal necrosis can be seen in the liver, kidney, and ...
Pituitary apoplexy (PA) is a rare clinical syndrome where the pituitary gland goes through infarction or hemorrhage, predominantly within the setting of an underlying cyst. We report on apoplexy of an expanding pituitary macroadenoma which was compressing the optic chiasm in a patient with progressive...
Uncovering TP53 Mutations in MDS, AML Requires NGS First Nonoperative Option Arrives for Low-Grade UTUC Radiation Oncology Leaders Bristle Over New Medicare Payment Model Tipifarnib Shows Potential in HRAS-Mutant Head and Neck Cancers Stage Is Set for Continued Progress in the Melanoma Clinic Making...
(AML) cells. Generally, AML is found in a person’s bone marrow. But in Cole’s case, the AML formed a rare tumor called a myeloid sarcoma, which is outside the bone marrow. Pathology revealed that the tumor’s chromosomal pattern was one that traditionally responds well to therapy. ...
Recent work has also demonstrated that heterozygous mutations in cohesin are a common (5–20 %) occurrence in patients with acute myeloid leukemia (AML) and related disorders [16, 17]. Given that AML samples rarely exhibit significant changes in chromosomal number, it again highlights that ...
Drug Administration (FDA) has granted luvelta a Fast Track designation for Ovarian Cancer, as well as Orphan and Rare Pediatric Disease designations for CBF/GLIS2 Pediatric AML. About Sutro Biopharma Sutro Biopharma, ...