this approach is reaching its limits. For one thing, the management style of leadership doesn’t guarantee happy or loyal managers or workers. Indeed, a large portion of American workers—56 percent—claim their
The interference from off-target toxic effects in these assays precluded the analysis of target engagement and prompted us to develop new approaches to determine ligand–RAS interaction in cells. To more directly query biophysical engagement of KRAS and HRAS with small-molecule target engagement in ce...
DUBNER: Everybody’s got a big “but,” as they like to say.“However, the other day,” Christina writes, “I came across the idea of ‘toxic positivity’ and was quite taken aback. Is it possible to have too much optimism and joy in my life?” You can just feel the air going...
all preferentially bind at sites of new cell synthesis and not at regions of ‘old’ cell wall. This has several important implications. First, it suggests that phages may have evolved to specifically recognize cells that are actively growing and are thus metabolically active...
In all 15 countries surveyed by McKinsey, toxic workplace behavior was thebiggest predictorof burnout symptoms and intent to leave—by a large margin. And toxic workplace behavior is more common than you might think: about one in four employees report experiencing some form of toxic behavior at...
This increases the vulnerability of the SN neurons so that a further insult from either toxic alpha-synuclein or mitochondrial dysfunction leads to cell death. It is the accumulation of all these processes that will lead to the loss of neurons within this brain region. Several of these processes...
The study, which focuses on New Orleans but may be applied to cities throughout the world, is the first to demonstrate how long-term changes in soil lead levels affect children’s blood lead levels. “Lead dust is invisible and it’s tragic that lead-contaminated outdoor areas are ...
Polluted air and steadily rising temperatures are linked to health effects ranging from increased heart attacks and strokes to the spread of infectious diseases and psychological trauma.
Modified biochar has been used to efficiently remove toxic metals from polluted areas, including arsenate As(V) (Rahman et al., 2021), lead, and cadmium (Wu et al., 2021). Engineered biochar has been effectively used to reduce the availability and transmission of heavy metal ions in soil ...
AI systems and predictionsamplify existing systematic biaseseven when the data is balanced. Nevertheless, more and more concerning uses of AI technology are appearing in the wild. This list aims to trackall of them. We hope thatAwful AIcan be a platform to spur discussion for the development ...