We calculated a killing index by calculating the bacterial viability measured after treatment with the small molecules and the bacterial viability after treatment with a vehicle control. The killing index is a ratio of the viability in the small molecule treated condition relative to the vehicle contr...
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Many studies from independent laboratories have implicated erythrocyte NO generation and/or delivery as a critical source of hypoxic vasodilation, although questions remain about the nature and stability of the molecule carrying “NO bioactivity”5,6,7,8. Other sources of NO for hypoxia-driven ...
A volume of 0.5 mL was used to estimate hematological parameters including PCV, Hb, total leucocytes count (TLC) and lymphocyte count (LC) according to Dacie et al. [25] and 3 mL was used to obtain serum for the measurement of lipid peroxidation (MDA) and reduced glutathione (GSH) ...
We aimed to identify the main native molecule(s) responsible for this effect and to elucidate its mechanism of action. Materials and methods Bacterial strains, media, and growth conditions In the study, we tested three Lactococcus lactis spp. lactis strains (Lc2, Lc3, Lc4), obtained from the...
Meng et al. verified that a novel small-molecule tyrosine kinase inhibitor (TKI), apatinib, could safely act as an antitumour rule in DTC by altering biological behaviour through the PI3K/Akt/mTOR signaling pathway. More importantly, the autophagy effects induced by apatinib could also provide a...
Inspired by the “like cures like” principle on cancer treatment in Chinese Medicine, we utilized the bioactive anti-cancer molecule Bufalin as a probe, which was originally extracted from Venenum Bufonis, a typical toxic Chinese Medicine to screen out AHSA1 as the potential target in MM by ...
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The OGTT consists exclusively of glucose, whereas the High Carb meal consists of sucrose, which is composed of one molecule of glucose, and one molecule of fructose. Unlike glucose in the OGTT, the fructose represented in the High Carb meal results in a more modest effect on blood glucose ...