green) and a quencher (yellow). Processing of N-QTF by Ag85 mycolyltransferase removes the quencher and integrates the fluorophore into the mycobacterial outer membrane. These ‘turn-on’ probes allow for monit
Department of Defense early Monday morning and then landed the first stage of its rocket back on solid ground. Going to work with mom: Shanghai's new approach to baby-sitting Aged just two and a half, Wu Rui follows her mother to work every morning, joining her peers in day care while...
Conventional chemotherapy or radiotherapy is still the most common treatment for solid cancers. DNA damage and other insults associated with these therapies can trigger therapy-induced senescence (TIS) in cancer cells and in other intratumoral cells, such as endothelial cells and fibroblasts20. The sen...
Ag2CO3 8.2×10−12 Saturated Solutions: Saturated solutions are equilibria between excess solid and dissolved ions. At this point, the rate of dissolution of the solid is equal to the rate of deposition of the ions. The equilibrium expression...
Fuel Processor Lifetime and Reliability in Solid Oxide Fuel Cells Desulfurization Removing sulfur compounds, i.e., desulfurization, is certainly a necessary process because commercial hydrocarbon fuels normally contain a small amount of sulfur contents. The sulfur-containing species will harmfully affect ...
The pyrenoid matrix is densely packed with the CO2-fixing enzyme Rubisco and is thought to be a crystalline or amorphous solid. Here, we show that the pyrenoid matrix of the unicellular alga Chlamydomonas reinhardtii is not crystalline but behaves as a liquid that dissolves and condenses during ...
Multiple solid tumors, including CRC, exhibit auxotrophy to arginine [92]. A key factor contributing to tumor vulnerability to arginine depletion is the expression of the ASS1 (argininosuccinate synthetase 1) gene. Numerous cancer cell lines and tumors of different cancer types have shown reduced ...
EcoTyper is a machine learning framework for large-scale identification of cell type-specific transcriptional states and their co-association patterns from bulk and single-cell (scRNA-seq) expression data. Ecotyper can be run in an easy-to-use web interface accessible here. The software can also...
e, Measured Ecell in units of the actual elastic moduli of the cells as a function of relative substrate stiffness obtained by fitting force–indentation curves simulated by FEM using a standard Hertz fit (equation (1)), or using the CoCS model fit (equation (5)). The right y axis ...
Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade, and remains difficult to treat. Furthermore, the molecular mechanisms underlying its development are still unclear. In this study, bioinformatics analysis showed that M