CD23 is a transmembrane protein expressed on the surface of B-lymphocytes that binds IgE, CD21, CD11b, and CD11c. High concentrations of soluble CD23 and L-selectin are found in the serum of patients with B-chronic lymphocytic leukemia (B-CLL). Because extracellular adenosine triphosphate (...
consistent with the known predominant Gs-coupling of GLP1R; however, co-application of GLP-1 with adenosine triphosphate (ATP), a strong activator of these neurons, resulted in significantly stronger Ca2+-signals than ATP application
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping. Disruption of OPA1 causes mitochondrial d
adenosine triphosphate β-OHB: beta-hydroxybutyrate CK: cytokeratin CoA: coenzyme A DMEM: Dulbecco's modified Eagle's medium EDTA: ethylenediamine tetraacetic aicd FCS: fetal calf serum Glut-1: glucose transporter type 1 H&E: haematoxyline-eosine HUVEC: Human Umbilical Vein Endothelial...
The protein possesses an extracellular ligand-binding domain composed of five Ig-like regions, followed by a transmembrane domain, a negative regulatory juxtamembrane intracellular domain, and a cytoplasmic protein tyrosine kinase domain split by an insert into adenosine triphosphate–binding and ...
Carbon starvation has been shown to induce a massive dispersal event in biofilms of the opportunistic pathogen Pseudomonas aeruginosa; however, the molecular pathways controlling this dispersal response remain unknown. We quantified changes in the proteome of P. aeruginosa PAO1 biofilm and planktonic cell...
Creatine is known to enhance creatine phosphate stores in muscles. These phosphates in turn create ATP or Adenosine Triphosphate, which is essentially a molecule that gives energy to the body and helps in all the basic life functions. When any exercise is carried out, ATP gets broken down to ...
Neurons depends on aerobic metabolism of glucose for supply of adenosine-5’-triphosphate (ATP). Fructose, an isomer of glucose in structure, is therefore not an ordinary fuel to neuron. However, fructose is able to generate pyruvate which enters the citric acid cycle as acetyl coenzyme A under...
We next analyzed mitochondrial function of cardiac muscle cells isolated frommitoNEETKO mice and control mice. Mitochondria produce adenosine triphosphate (ATP) by the oxidative phosphorylation system, which consists of complexes I–IV of the electron transport chain. Mitochondrial respiration is classified...
a potential link between JNK and ER stress during the in vitro HSC activation process, we treated primary mHSCs with non-toxic (Suppl. Fig.2) concentrations of an adenosine triphosphate (ATP)-competitive inhibitor of JNK (JNK V inhibitor) from the moment of seeding. After 7 days in culture...