Amphiphilic additives improve drug solubility in water by trapping molecules and forming nanoscale aggregates; micelles35,36. DMSO and NMP are polar solvents. The addition of Kolliphor®HS 15, an amphiphilic nonionic surfactant formerly known as Solutol HS 15, to DMSO dramatically increased RFB solu...
The time course studies of growth and lipase production in the optimal medium revealed that the highest lipase production was achieved at the end of the log phase of growth, reaching the value of 35.0 U cm-3 in the fifth day of cultivation. The effects of various polar, water-miscible, ...
phosphorous pentoxide, acidic ion-exchange resin, molecular sieves, acidic clay, silica gel and combinations thereof in a water miscible solvent like acetonitrile or immiscible solvent like dichloromethane at room temperature to bind water to form a insoluble complex which shifts the equilibrium towards ...
However, insoluble matter and some fine particulates in the suspension were still noticeable. PG is less viscous than glycerin and a better emulsifier and solvent. In contrast with glycerin, it is miscible with several apolar solvents. These benefits might explain why a more homogenous and ...
For an efficient enrichment, the ideal mobile phase should be water miscible, but not contribute any hydrogen donor or acceptor functionalities. A completely aprotic solvent such as acetonitrile embraces this particular feature and thus is often used for glycopeptide enrichment by HILIC SPE. However, ...
The compound (2) can be prepared of the process disclosed in WO2001032652 application or by a process comprising reacting compound (7) with compound (8) in a suitable solvent, for example acetonitrile, in a presence of NaI: The concentration of compound (7) in the solvent can be between ...
46. A process for preparation of the polymorph of claim 4 comprising: (a) dissolving N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4,5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide in acetonitrile to obtain a solution, and (b) adding water to the solution.Description...
per cent of the monomers have polymerized, and thereafter adding during the polymerization one or more quaternary ammonium monomers as referred to above (which may be the same as or different from any such monomers previously used) and one or more water-miscible organic solvents in sufficient ...
Specified solvents are N:N-dimethyl formamide, N:N-dimethyi acetamide, dimethyl sulphoxide, formic acid, acetonitrile and tetrahydrofurane. Specified non-solvents are water, methanol, ethylene glycol and glycerol. Specified inorganic compounds are calcium carbonate, magnesium carbonate, clay, collcidal...
The effect of various water-miscible organic solvents (ethanol, methanol, acetone, acetonitrile, N,N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO)) on the kinetics of 4-tert-butylcatechol (tBC) oxidation in the presence of different samples of organic solvent-resistant tyrosinase (OSRT) has...