Longer observation invervals might increase the positive predictive value of a nonreactive nonstress test (NST). One thousand one hundred and one NSTs were performed on 343 fetuses in 333 high-risk hospitalized patients. Recordings were terminated when five fetal heart rate (FHR) accelerations with...
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Stress is a major risk factor for physical and psychological health problems1and has been strongly linked to the onset of major depressive disorder (MDD)1,2. Although ‘stress’ is often broadly defined, prior research has divided this construct into ‘good stress’, ‘tolerable stress’, and ...
The selective genetic removal of APOE4 from neurons led to a significant reduction in tau pathology, gliosis, neurodegeneration, neuronal hyperexcitability and myelin deficits. Single-nucleus RNA-sequencing revealed that the removal of neuronal APOE4 greatly diminished neurodegenerative disease-associated ...
Quality is a rather slippery concept, and its assessment in subtitling can be a challenging task, as its appreciation can easily vary depending on the diff
Oxidative stress 1. Introduction The Free Radical or Oxidative Stress Theory of Aging postulates that reactive oxygen species (ROS) formed exogenously or endogenously from normal metabolic processes play a role in the aging process. The imbalance of pro-oxidants and antioxidants leads to an age-relat...
To elucidate how cell death lowers MUFA-PI levels, we first investigated whether the availability of non-esterified MUFAs and lyso-PI (LPI) is affected by cytotoxic stress in fibroblasts. Prin- cipal component analysis shows that the MUFAs 16:1 and 18:1, located in the lower left quadrant,...
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Accumulating evidence shows that obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease. However, there are no published prospective studies on the relationship between OSA and the progression of arterial stiffness.