Healthy metabolic measures in humans are associated with longevity. Dysregulation leads to metabolic syndrome (MetS) and negative health outcomes. Recent e
d, NanoString analysis with a metabolism panel to analyze relative fold changes in large-intestine samples gathered from six 24-month-old and six 4-month-old mice. ‘Decr.’ and ‘incr.’ refer to genes with a relative fold decrease and relative fold increase of their transcripts, ...
Mattson calls this “metabolic switching”. Intermittent fasting means this happens over the long term and your body also begins to find it easier to access your fat stores for energy. This is important because there are nine calories in a gram of fat and only four calories in a gram of ...
Metabolic Syndrome with Fasting Hyperglycemia Is More Common in Ethiopian Israelis Than West Africans or African AmericansANNE E. SUMNERMICHAEL G. KNIGHTCHARLES N. ROTIMIANAT JAFFE
C. et al. Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes 54, 702–711 (2005). Article CAS PubMed Google Scholar Girard, J. R. et al. Fetal metabolic response to maternal fasting in the rat. Am. J. Physiol. 232,...
Intermittent Fasting is your ticket to a long and healthy life because it mimics the only proven way to increase lifespan, caloric restriction. Watch.
Interactions between adipose tissue, liver and immune system are at the center of metabolic dysfunction-associated steatotic liver disease and type 2 diabetes. To address the need for an accurate in vitro model, we establish an interconnected microphysio
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting more than 25% of the human population, and a leading cause of morbidity and mortality [1]. NAFLD, considered the hepatic manifestation of metabolic syndrome, and its earliest stage,...
Here, we identify the arginine metabolizing enzyme, arginase 2 (Arg2) as a hepatocyte glucose fasting-induced factor that is sufficient to convey the adaptive hepatic and peripheral metabolic changes induced during CR and IF. Hepatocyte Arg2 mRNA and protein expression is induced during acute and ...
The aims of the present study were to determine the effect of the PI3K/Akt/eNOS signaling pathway on erectile function in a rat in vivo model of MED and to suggest a potential novel treatment strategy for MED. Results Metabolic Parameters Body weight, fasting blood glucose, plasma total choles...