Lipid soluble antimicrobials that are weakly alkaline with a high pKa are most likely to adequately cross the blood-prostate barrier (Niżański et al., 2014). Early work using dogs as a model for human disease indicated that trimethoprim (but not sulfonamides) had good prostate penetration (...
Type 1 innate lymphoid cells (ILC1s) are a class of tissue-resident cells with antitumor activity, suggesting its possible role in solid tumor immune surveillance, but it is not clear whether manipulating ILC1s can induce potent antitumor immune response
pKa value mean and what does it tell you? Why is it important? Bronsted-Lowry Acid:A Bronsted-Lowry acid species contains at least one ionizable covalent "H-X" bond in its molecular structure. A simple example is hydrochloric acid, in which the one and only covalent ...
It is a branch of natural science that examines the building blocks of matter, including the atoms, molecules, and ions that make up compounds and their composition, structure, behaviour, and changes that occur when they interact with other things. The quantum mechanical approach is currently used...
(gray) or different hAQP10 forms (cyan, blue and red). Pglyis normalized for each dataset ((Pgly-Pgly control)/Pgly max) and fitted with a Hill equation. Corresponding internal pH (pHin) is also shown (lower axis). Results are given as mean ± SD of at leastN = 3 ...
What is the pKb of a base whose conjugate acid has a pKa of 11.54? Acid-Base equilibrium. The acid in aqueous solution gives a proton and the base accepts it. The number of protons in a solution is measured by pH. The strength of acid and base is measured by {eq}k_a ...
pKa of the protonated Schiff base and aspartic 85 in the bacteriorhodopsin binding site is controlled by a specific geometry between the two residues. Biochemistry, 1995, 34:12059-12065.Rousso, I., Friedman, N., Sheves, M., and Ottolenghi, M. (1995) pKa of the protonated Schiff base and...
BCECF fluorescence was excited alternately at 495 ± 10 and 440 ± 10 nm, and the emitted light was collected through a bandpass filter (520–550 nm). Fluorescence ratios (495 nm/440 nm) were obtained at 1 Hz and converted into pHi using the high K+/nigericin calibration approach (16)....
Conjugate acid-base pair : A single proton separates two molecular units. What Is Buffer Capacity and What Does It Mean? The amount of acid that buffers can absorb before breaking the capacity for adding strong acid is referred to as buffer capacity. When adding a strong acid, solutions wi...
Differences were assessed by a two-tailed unpaired t-test, using 2 biological replicates and 2 technical replicates per biological replicate, Mean ± SD. c. PRM showing R. N. I. of peptide associated with phosphorylated serine at 158 of Hox7 during appressorium development in pmk1as ...