Giant cell glioblastoma is a distinctive subtype of glioma characterized by vulnerability to DNA damage.doi:10.1007/S10014-019-00355-WKaoru OgawaAkira KuroseAkihisa KamatakiKenichiro AsanoKosuke KatayamaHidekachi KurotakiSpringer Singapore
FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions Masuko Katoh Yohann Loriot Masaru Katoh Nature Reviews Clinical Oncology(2024) OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway ...
Despite numerous reports indicating the significant impact of RNA modification on malignant glioblastoma (GBM) cell behaviors such as proliferation, invasion and therapy efficacy, its specific involvement in glioblastoma (GBM) angiogenesis is remains unc
One of the first cell-SELEX procedures was performed in 2003 with a glioblastoma-derived cell line (U251).32 Twenty-one rounds of cell-SELEX were performed, and the sequences obtained were cloned and sequenced. The analysis of these sequences led to the identification of a predominant aptamer...
glioblastoma, differentiated and medullary thyroid cancer, triple negative breast cancer, hepatocellular carcinoma and renal cell carcinoma (RCC) [1,2,3]. In contrast to prostate cancer, the high tumor uptake on PSMA PET in these tumors is primarily caused by a high expression of PSMA-receptors ...
CRP was upregulated on one locus on gene level in glioblastoma tissue as compared to non-tumor brain tissue, but not in glioma stem cells as compared to neural stem cells. The structure of the CRP protein was a characteristic pentamer in both humans and rats. Both human and rat glioblastom...
The objective of the present study was to test the involvement of extracellular ATP in glioblastoma growth in a rat glioma model. Methods To deplete the extracellular ATP, the enzyme apyrase was tested on the treatment of gliomas implanted in the rats CNS. One million glioma C6 cells in 3 ...
GliomaMicroarrayMouse modelTemozolomideTumor progressionTumor suppressorCaveolin-1 (Cav-1) is a critical regulator of tumor progression in a variety of cancers where it has been shown to act as either a tumor suppressor or tumor promoter. In glioblastoma multiforme, it has been previously demonstrated...
Abstract 2522: S100A4 is a critical regulator of stemness and the mesenchymal phenotype in GBMs Glioblastoma (GBM) is one of the most incurable human cancers, and the mesenchymal subtype of GBMs has the worst prognosis. The mesenchymal phenotype and glioma stem cells (GSCs) are associated with...
Glioblastoma is a highly malignant tumor that easily acquires resistance to treatment. The stem-cell-like character (stemness) has been thought to be closely associated with the treatment resistance of glioblastoma cells. In this study, we determined that farnesyl diphosphate synthase (FDPS), a key...