Asymmetric division proceeds from the polar-associated septum, producing the two different cell types, each of which contains a complete genome. The larger compartment is the mother cell and the smaller is the forespore. σF was formed during Stage I before the septum was complete and thus is...
Future work will be required to identify gene–gene and gene–environment interactions on a genome-wide level, with the aim of fully elucidating the genetic risk factors for asthma and atopy, understanding the path- ogenesis of these common diseases, and perhaps devising new treatment strategies ...
The genome ofUS. plumacontains all genes for the oxidation of zero-valent sulfur (S0), or thiosulfate as typically described for the genusSulfurimonas, but it misses the genes for sulfide:quinone reductases (sqr), a functional-core gene for this genus (Fig.3and Supplementary Table5). Notably...
Age and sex are major risk factors in Alzheimer’s disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease pathogenesis and is inexorably linked with inappropriate microglial ac
In his talk at TED2012, researcher and jungle genome operative Nathan Wolfe makes the point that until 1898, when Dutch microbiologist Martinus Beijerinck published a paper showing that something smaller than bacteria were causing diseases, something he called a virus, we had no idea that an ent...
According to criteria proposed by the International Committee on Taxonomy of Viruses (ICTV), members of the same picornavirus genus should share greater than 40%, 40% and 50% amino acid identities for P1, P2 and P3 regions of the genome, respectively. Considering these criteria, all known ...
Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can yield detrimental outcomes, a role in facilita
Recent exceptional longevity (EL) genome wide association studies have facilitated estimation of an individual’s polygenic risk score (PRS) for EL. We tested the hypothesis that individuals with high ELPRS have a low prevalence of MetS. Participants were from five cohorts of middle-aged to older...
using a forward-genetics approach, we identify regions of the genome harbouring mutations that affect tail length. We link changes in expression of a gene in one of these regions,Hoxd13, to differences in PSM size and its neuromesodermal progenitors (NMPs) as a likely developmental mechanism ...
We used the Spearman correlation to create a global, genome-wide metric that considers all detected transcripts instead of focusing on a subset of individual genes. We defined the length correlation (ρTI) as the Spearman correlation between transcript lengths and relative fold changes. We found th...