Keywords: Intrathecal infusionpumpbaclofeninfectionBackground. Intrathecal baclofen administration by means of an implantable pump is nowadays a safe and effective method in the treatment of spasticity. One of the rare but devastating complications of this technique is pump infection, with a variety of...
Drugs and Infusion Procedures The GABA-A receptor agonist muscimol and the GABA-B receptor agonist (RS)-baclofen (Tocris Bioscience, UK) were dissolved in saline. In all regions 1.0 nmol/0.3 ml baclofen and 0.1 nmol/0.3 ml muscimol (B&M) was administered, with the exception of the NAcc ...
The neural substrates of social play are incompletely understood, but there is evidence to support a role for the prefrontal cortex (PFC) and striatum in this behavior. Using pharmacological inactivation methods, ie, infusions of GABA receptor agonists (baclofen and muscimol; B&M) or the AMPA/...
A client with multiple sclerosis has been prescribed baclofen. The nurse teaches the client about the action of the drug. Which of the following is an accurate instruction regarding this drug’s action A. "Baclofen will decrease your fatigue and help increase your energy levels. "B. "Baclofen...
A client with multiple sclerosis has been prescribed baclofen. The nurse teaches the client about the action of the drug. Which of the following is an accurate instruction regarding this drug’s action A. "Baclofen will decrease your fatigue and help increase your energy levels. "B. "Baclofen...
AIV Inactivation with Muscimol + Baclofen The statistical analysis of lever presses during the 120-min tests, which included the between-subject factor of Muscimol + Baclofen (M+B) dose and the within-subject factor of lever, showed a significant main effect of M+B dose (F1,20 = 9.1, p ...
Retrospective case notes review of nine children admitted with SD at our tertiary paediatric centre looking at underlying neurological diagnoses, age of onset of dystonia, concomitant anti-dystonia medication, intrathecal baclofen pump with rate of daily infusion, anti-reflux medication, gastroenterological...