Cellular reprogramming consists of the loss of differentiated cell identity followed by the acquisition of embryonic stem pluripotency, which can be achieved by the simultaneous expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM; in mice encoded byPou5f1,Sox2,Klf4andMyc, respect...
Hox proteins have similar binding specificities in vitro, yet they control different morphologies in vivo. This paradox has been partially solved with the identification of Hox low-affinity binding sites. However, anterior Hox proteins are more promiscuo
While vetting is important to make sure quality options are chosen and poor options are discarded, the process can also be time-consuming and expensive. As such, a balance must often be struck between the costs and benefits of vetting. The average organization in the U.S. spends about $4,...
An index like the S&P MidCap 400 gives investors access to a more diverse base of securities. That's because there's a wide range ofsectorsrepresented on the index and many more stocks. Therefore, it can help cut down on an investor'smarket risk. Unlikelarge-capcompanies, there is usuall...
4e did bring in a bunch of new players who hadn't been interested in D&D before, but it wasn't enough to make up for the massive loss of old fans who just couldn't accept the enormous changes to the system.Thus, the purpose of 5e was clear: bring back those old players, while ...
Dynamin related protein 1 (DRP1), a pivotal mitochondrial fission protein, is post-translationally modified by multiple mechanisms. Here we identify a new post-translational modification of DRP1 by the ubiquitin-like protein, interferon-stimulated gene 1
processors have wide-ranging commercial applications, and are found in a multitude of mobile and desktop devices. with vpro™ technology – designed and developed by intel ® , the renowned processor manufacturer – you can ensure that your it department is able to keep up with data demands ...
./sbt testNote: please note that we are not using here a system wide sbt, but our own copy of it (under ./sbt). This is primarily done for determinism. In order to have a reproducible build, the helper script needs to be part of the repo....
After DNase I incubation, the superna- tant was removed, and the tissues were triturated with a widebore P1000 pipette tip in complete culture medium (DMEM/F12K medium supplemented with 10% FBS and 1% antibiotic–antimycotic solution). The debris was allowed to settle for 2 min, and ...
Biodiversity(生物多样性), or biological diversity, is a wide-ranging concept that covers all the different kinds of plant and animal species present on earth. Environmentalists believe that many millions of species exist. As all these living organisms are dependent on each other...