The long-term effects of taking melatonin are not well understood, said Grover and Kole. "There are not a lot of major studies," Grover said. If children use melatonin for too long, they may develop a tolerance to it, leading to higher andhigher dosesneeded to be effective, said Grover...
Melatonin significantly enhanced survival of glial cells (as revealed by glial cell specific markers, glial fibrillary acidic protein and aquaporin-4 immunostaining) at both time periods postischemia, and the preservation of these glial cells in the ischemic penumbra corresponded with a markedly reduced...
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