Programmed-cell death is an antimicrobial defense mechanism that promotes clearance of intracellular pathogens. Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades lytic cell death
Article https://doi.org/10.1038/s41467-025-56128-x The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death Received: 24 October 2022 Accepted: 7 January 2025 Check for updates Margarida T. Grilo Ruivo 1, Ji-hun Shin2,6, Todd Lenz 3,6, ...
Then, the cell graph is pruned from selecting an adaptive number of neighbors for each node on the KNN graph by removing the noisy edges3. Fig. 2: The architecture of scGNN Autoencoders. a The feature autoencoder takes the expression matrix as the input, regularized by LTMG signals. The ...
The market return is given by the value-weighted return of all 2087 cryptoassets. Even though a large universe of cryptoassets exists, the market is highly concentrated around a few cryptocurrencies. Combined, Bitcoin and Ether account for 69% of total market capitalization, which resembles in a...
In 1982, James Kruger, John Pappenheimer and Manfred Karnovsky identified a sleep-promoting small molecule in the cerebral spinal fluid and urine of humans and animals1. This sleeping factor turned...
Formyl peptide receptor 1 (FPR1), a G protein-coupled receptor expressed in phagocytes, recognizes short N-formylated peptides originating from proteins synthesized by bacteria and mitochondria. Such FPR1 agonists are important regulators of neutrophil functions and by that, determinants of inflammatory...
I wrote a code to produce twin primes, however it is pretty strenuous for my computer and I need some high numbers to check a conjecture. Is there a better way to get twin primes. Note: these twin primes are represented by 6m's where 6m+-1 ...
To test the ability of ΔROP55 to complete the lytic cycle in human foreskin fibroblasts (HFFs) we performed plaque assays over 6 days. We observed a trending reduction in both size and number of plaques (Fig.2c, d), when compared with the wild type line (WT), and this phenotype was...
Human beings are made of ~50 trillion cells which arise from serial mitotic divisions of a single cell - the fertilised egg. Remarkably, the early human embryo is often chromosomally abnormal, and many are mosaic, with the karyotype differing from one ce
Lopez-Vicente, A. Mazo, M.E. Lleonart, J. Castellvi, S. Ramon y Cajal p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors Oncogene, 30 (2011), pp. 2087-2097, 10.1038/onc.2010.614 View in ScopusGoogle Scholar [23] V. Garcia, ...