The ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by the α-ketoglutarate-dependent dioxygenase AlkBH3. Other ASCC components
MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma ce
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[Moved to: https://github.com/alphaSeclab/awesome-cyber-security ][Draft]Awesome Cyber Security Resource Collection. Currently contains 8000+ open source repositories, and not very well classified. For each repository, extra info included: star count, co
Target dose was 100mg/m2. Intravenous mFOLFOX6 was administered on the same day at the standard dose. Dose limiting toxicity (DLT) was defined as leukopenia ≥ grade 4, thrombocytopenia ≥ grade 3, febrile neutropenia ≥ grade 3, and other nonhematologic toxicity ≥ grade 3. Results Fifteen...
lactis ADI and the Lc4 strain as promising, potential therapeutic agents with broad applicability.Background Colorectal cancer (CRC) is a life-threatening disease with one of the highest global prevalence and mortality. Based on the World Health Organization (WHO) statistics, 2 million new cases ...
The recent blooming of metabarcoding applications to biodiversity studies comes with some relevant methodological debates. One such issue concerns the treatment of reads by denoising or by clustering methods, which have been wrongly presented as alternat
We and others identified the tumour-suppressor lethal (2) giant discs (Lgd)/CC2D1 as a physical interactor of Shrub/CHMP4 in Drosophila and mammals, respectively. Results Here, we show that the loss of function of lgd constitutes a state of reduced activity of Shrub/CHMP4/ESCRT-III. This...
Overall, these data reveal that Asxl2 is required for normal haematopoiesis and has distinct and non-redundant effects compared with Asxl1 in haematopoiesis. Asxl2 is required for haematopoietic stem cell self-renewal. We next assessed the effect of Asxl2 or compound Asxl1/2 loss on HSPC ...
Reduction of microtubule-associated protein 2 (MAP2) immunoreactivity (MAP2-IR) is present in individuals with Sz, despite no change in MAP2 protein levels. MAP2 is phosphorylated downstream of multiple receptors and kinases identified as Sz risk genes, altering its immunoreactivity and function. ...