ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to identify ISG15-binding proteins and discover Ring ...
In addition to increasing the expression of programmed death-ligand 1 (PD-L1), tumor cells can also secrete exosomal PD-L1 to suppress T cell activity. Emerging evidence has revealed that exosomal PD-L1 resists immune checkpoint blockade, and may contrib
Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized in preclinical
Furthermore, the M3-type strain produced the lowest absorbance values in a crystal violet assay, indicative of lower cell biomass, as compared with the other wild-type strains. These experiments confirm previous observations [1, 28] that GAS strains have varying capacity to form biofilm in vitro...
1. Introduction Most modern vaccines are composed of recombinant proteins. Unlike entire pathogens, these molecules are often considered by the organism as negligible inconvenience, and no immune response is induced against the antigen [1]. To stimulate the immune system, pathogen-associated danger sig...
Cell wall components encompassing the bacterial glycome can include lipopolysaccharides in Gram-negative bacteria, glycosylated teichoic acids in Gram-positive bacteria and peptidoglycan, exopolysaccharides, capsular polysaccharides, glycolipids as well as glycoproteins in both types of bacteria. Bacterial ...
Results: We identified steroid-sensitive gene 1 (SSG1) as being regulated by PKG in vascular cells. Conclusion: SSG1 functions as a PKGI kinase target and interacting partner in cardiovascular tissues. Significance: Identifying new PKGI effectors may improve the understanding of the pathophysiology ...
mamX, and 6.55±1.88 for CmamX(Table1). The number of intracellular magnetosomes was slightly higher in ∆mamXthan in the other two strains. An energy-dispersive spectroscopic analysis showed that iron and oxygen were the primary elemental components of magnetosomes in ∆mamX, the same ...
45 set by the Jiangsu Provincial People's Government. The ARRIVE guidelines was provided as Additional file 1. Samples collection After 10 weeks feeding, goats were slaughtered after overnight fasting. Immediately after slaughter, the abdominal cavity was opened by midline incision, after that the ...
The Rnf activity eluted as a single peak from a gel filtration with an activity of 2.1 U/mg (Supplementary Fig.2). This procedure enriched the activity 21-fold with a yield of 13% (Supplementary Table1). When the preparation was analyzed by SDS-PAGE, more than the expected six ...