In this report, we first carried out density functional theory (DFT) computations to derive suitable charges for the Fe2+-containing heme group of P450 enzymes. Then, by means of the homology modeling technique, and taking advantage of the recently published crystal structure of the human CYP2...
With the aim to introduce environmentally friendly alternatives over conventional chemical catalyst, a variety of enzyme-mediated synthesis of PEDOT: PSS have been developed in recent years by introducing proteins containing iron in a heme complex (horseradish peroxidase [1], soybean peroxidase [8], ...
High-valent nonheme iron-oxo complexes: synthesis, structure, and spectroscopy. Coord. Chem. Rev. 257, 414–428 (2013) Article CAS Google Scholar Rosa, A., Ricciardi, G. & Baerends, E. J. Is [FeO]2+ the active center also in iron containing zeolites? A density functional theory ...
W. Heme uptake in bacterial pathogens. Curr. Opin. Chem. Biol. 19, 34–41 (2014). 8. Schryvers, A. B. & Morris, L. J. Identification and characterization of the transferrin receptor from Neisseria meningitidis. Mol. Microbiol. 2, 281–288 (1988). 9. Noinaj, N. et al. ...
The activation of dioxygen or hydrogen peroxide and action of DNA cleavage by iron complexes including non-heme, heme and simple models are a great topic of bioinorganic, medical and pharmaceutical fields.1, 2, 3, 4, 5 For example, bleomycins (BLMs) are a family of antitumor antibiotics us...
(a complex in which ferric ions are bonded to an amino acid or a peptide), heme iron bonded to animal protein, or nonheme iron bonded to vegetable protein. This iron bonds with as many as 200 different types of enzymes in the body and supports vital activities. It is also responsible ...
prosthetic groupanalytical techniquesreversible bindingdioxygencooperativityoxygen bindingChemists began working on model compounds for myoglobin and hemoglobin in the early 1970s. The discussion in this chapter will be on: (1) structure of the active heme site of myoglobin and hemoglobin as determined ...
The oxidative transformations mediated by heme-containing metalloenzymes, such as peroxidases, cytochrome P450 and nitric oxide synthase (NOS), have attracted sustained attention. In this study, various synthetic iron porphyrins were used as enzyme models to study the reactive intermediates and the ...
Construction and Crystal Structure Analysis of Heme Acquisition Protein HasA Containing Iron(III)‐5,15‐Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Groupsynthetic porphyrins · heme proteins · Artificial HasA · protein structures · growth inhibition...
A new five coordinate and stable iron(III) heme analog, [Fe III(OEP)(DicydH)], where OEP is the dianion of octaethylporphyrin and DicydH = monoanion of 1,4-phenyldicyanamide, has been synthesized. The compound has been characterized by different spectroscopic methods 1H NMR, UV–Vis, IR...