However, the very short plasma half-life and poor oral activity of DFO led to the development of two new orally active iron chelators for the treatment of transfusional iron overload, the bidentate deferiprone (DFP) and the tridentate deferasirox (DFX). All three of these chelators, which ...
Patients with recent major surgery within the last three months, use of erythropoietin stimulating agents, blood transfusions within a six-week time period, a history of cirrhosis, and/or a diagnosis of end stage renal disease receiving IVIR were excluded. ID in HFrEF is defined as ferritin ...
Iron overload can be classified into two types: primary hemochromatosis (mutations in genes responsible for iron absorption and regulation), and secondary iron overload (therapeutic interventions, such as repeated blood transfusions to treat hemolytic anemia and excessive iron supplementation to stimulate ...
Iron overload can be classified into two types: primary hemochromatosis (mutations in genes responsible for iron absorption and regulation), and secondary iron overload (therapeutic interventions, such as repeated blood transfusions to treat hemolytic anemia and excessive iron supplementation to stimulate ...
Iron deficiency results in decreased exercise performance in rats, corrected rapidly by iron but not by blood transfusion [30, 31]. In HD patients iron deficiency without evidence of iron deficiency anemia has been reported, and IV iron repletion was associated with positive effects on serum ...
In thalassemia major, due to ineffective erythropoiesis, regular blood transfusions are needed and this may lead to excess iron deposition in the liver and heart. These patients are lost due to cardiac failure and cardiac complications that occur as a result of iron deposition in the heart. In...
In addition, about one-fifth of all patients received blood transfusion (N = 49), while parenteral iron was given to only four patients. Figure 4 shows rates of conducted parenteral iron therapy for all of the participating centers. Figure 4. Parenteral iron therapy, % (all four centers ...
A chelating drug is effective if it causes an increase in iron excretion at a rate higher than the rate of iron intake from transfusions and iron absorption. In contrast to chelators intended for the treatment of iron overload, iron chelating drugs intended for the treatment of iron ...
For example, iron toxicity is common during iron overload states associated with genetic factors or acquired factors such as repeated blood transfusions. 2.2. Oxidative Stress Reactive species are formed as the result of normal metabolic processes. However, the human body is equipped with detoxifying...
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