Iron absorptionmay be regulated both at the stage of mucosal uptake and at the stage of transfer to the blood. Recent studies show that in mice HIF-2α, a mediator of cellular adaptation tohypoxia, regulates transcription ofSLC11A2(the gene encodingdivalentmetal transporter 1, DMT1) and thus...
The former was built using CpG markers of whole blood cells, which were processed with the Illumina Infinium HumanMethylation450 BeadChip, and the latter applying 51 types of human tissues and cell types analyzed by Illumina Infinium HumanMethylation27 or 450 BeadChip [46, 47]. IEAA, derived ...
Predictive Value of CHr—a Real-Time Iron Parameter There were strong correlations between CHr at 4 mo and erythrocyte parameters at 6 mo for both groups (Spearman correlation r for Hb: 0.38, P = 0.003; MCV: 0.76, P < 0.001; RBCs: −0.31, P = 0.02; red blood cell distribution ...
range.Serum ferritinis low in this stage. The second stage is characterized by the detection of abnormal ironserologies, such as reducedtransferrin saturation, increased total iron-binding capacity, and increasedzinc protoporphyrin. The third and final stage demonstrates a hemoglobin concentration of ...
Serum iron concentration (SI), Total Iron Binding Capacity (TIBC), Transferrin Saturation Fraction (TSF) and Packed Cell Volume (PCV) showed mean values of 16.60 ± 2.93umol/l, 62.20 ±4.02umol/l, 27.20 ± 3.00% and 0.398 ± .030l/l respectively for the blood donors. These values were ...
Hence, this study aimed to assess the association between iron biomarkers and cardiovascular disease risk factors (CVD-RFs–cholesterol, blood pressure, glucose metabolism) in two ways. Firstly, we explored the interaction between menopause and iron status regarding the association between iron status ...
absorption [30]. The area under the curve (AUC) can be calculated using the trapezoidal rule [30]. A final blood sample can be collected 14 days later to determine the erythrocyte isotopic composition for calculating overall iron bioavailability from the test dose (as described in the next ...
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis. Numerous studies have conducted comprehensive analysis of c-di-GM
A sample of 12 mL of venous blood was withdrawn from each subject using a plastic syringe fitted with a steel-free catheter to avoid Fe contamination after a fasting period of at least 8 h. First, 2 mL of blood were used for the determination of hematological parameters using an automatic...
RBC Red blood cell RBCIU Red blood cell iron utilization TfR1 Transferrin receptor 1 TSAT Transferrin saturation References Marx, J.J. Iron absorption and its regulation. A review. Haematologica 1979, 64, 479–493. [Google Scholar] Ricketts, C.; Cavill, I.; Napier, J.A.; Jacobs, A. ...