Iron participates in various crucial metabolic processes as an essential cofactor of many enzymes, which are vital to the survival of plants and their pathogens. However, excessive iron is toxic to the cells of plants and pathogens. Iron plays a complex role in the interactions between plants and...
In addition, iron plays a central role in many environments as an energy source for some microorganisms. This review is focused on Fe(II) oxidation. The fact that the ability to oxidize Fe(II) is widely distributed in Bacteria and Archaea and in a number of quite different biotopes ...
Normally, the lysosome plays an integral role in cellular iron homeostasis by facilitating both the delivery of iron to the cytosol (e.g., after endocytosis of the iron–transferrin–transferrin receptor complex) and the cellular recycling of iron. During a lysosomal storage disorder...
Iron plays an important role in many biological processes but it has low solubility under physiological condition. Many microorganisms have been shown to be able to circumvent this nutritional limitation by forming direct contacts with iron-containing proteins through ATP-binding cassette (ABC) ...
Iron is an essential trace element that is vital for the physiological functioning of the human body. It plays a significant role in the biosynthesis of iron-sulfur (Fe–S) clusters and heme within mitochondria; these iron-containing structures serve as cofactors for numerous enzymes [1,2,3]....
Iron plays a central role in proteins essential for respiration in almost all living cells. In common with most eukaryotes,T. gondiicontains iron2which is required for a number of essential cellular processes, including heme biosynthesis3,4, iron sulphur (Fe-S) cluster biogenesis5and as a ...
Point 1. Iron plays a key role in inducing ferroptosis. Point 2. An imbalance in energy metabolism is closely associated with ferroptosis. Point 3. Iron is involved in the metabolism of glucose, lipids, and amino acids, and is thus associated with energy metabolism. ...
Integral for hemoglobin synthesis, iron also plays an important role in many cellular processes; particularly, oxygen transport and storage, generation of energy through oxidative phosphorylation [1] and enzyme function affecting intracellular metabolism [2]. In addition, iron assists i...
As a growth limiting factor, iron plays an essential role in the growth and reproduction of mammals and a wide range of pathogens [5]. As a highly iron-dependent pathogen,Salmonellauses iron from the host to promote its own intracellular survival and reproduction [6,7]. However, the detailed...
Accumulating evidence suggests that the bone marrow microenvironment, or the stem cell niche, plays an important role in maintaining hematopoietic stem/progenitor cells through the secretion of various cytokines and by direct cell-to-cell interactions [33,43]. In this study we found that, in additi...