Iron overload disorders: treatment options for patients refractory to or intolerant of phlebotomy. Pharmacotherapy 2008 Mar;28(3):331-42.Bring P, Partovi N, Ford JE, Yoshida EM (2008) Iron overload disorders: treatment options for patients refractory to or intolerant of phlebotomy. ...
In hemochromatosis, this regulatory mechanism is impaired and an excess amount of iron is absorbed from the intestines regardless of the iron stores already in the body, resulting in iron overload. Because the body does not have a mechanism to rid the excess iron, this imbalance between gains ...
Iron levels in iron overload mice and rats treated daily with DFO-NPs:a,bUrinary iron excretion and efficiency of DFO-NPs treatment via IV and SC injection compared to saline and DFO treatments at 4 h post-injection. Dotted line inaindicates physiological reference levels from CD-1 mice fe...
iron overload. Therefore, melatonin may become potential complementary therapy for iron overload-related disorders due to its iron chelating andantioxidant activities. Here, the research progress of iron overload is reviewed and the therapeutic potential of melatonin in the treatment of iron overload ...
Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like defero
The recommended treatment for thalassaemia major is regular blood transfusions, although these lead to the harmful accumulation of iron in the body. If untreated, iron overload is responsible for heart, liver and endocrine diseases. The only two iron chelating agents available for the treatment of...
INTRODUCTION: Transfusional iron overload can lead to hepatic fibrosis, arrhythmias and congestive heart failure and a number of endocrinopathies. Deferiprone is an oral iron chelator recently approved for use in the United States as a second line agent for the treatment of transfusional iron over...
To the Editor:Despite the widespread use of iron, cases of secondary iron overload are exceptionally rare.1,2We present a case of iron overload after the prolonged administration of intramuscular iron.A 63-year-old woman was found to have a raised serum iron level. In 1950 intramuscular admi...
To determine whether the orally active iron chelator deferiprone (1,2-dimethyl-3-hydroxy-pyridin-4-one) is efficacious in the treatment of iron overload in patients with thalassemia major, we conducted a prospective trial of deferiprone ... NF Olivieri,GM Brittenham,D Matsui,... - 《N Engl...
Heart disease is the main cause of death in people who haveβ-Thalassemia Major in countries using safe,adequate blood supplies.Iron chelation therapy have led to dramatic improvement in survival of patients withβ-TM.The prevention and control of iron overload is an achievable goal to avoid or...