It can check for conditions like anemia, or iron overload (excess iron). Your doctor might order a test if you have symptoms of either condition. Symptoms of low iron include: Tiredness Dizziness Weakness Headaches Pale skin Fast heartbeat Symptoms of high iron include: Joint pain Tiredness ...
Hereditary hemochromatosis is an iron overload disorder that can lead to the impairment of multiple organs and is caused by mutations in one or more different genes. Type 1 hemochromatosis is the most common form of the disease and results from mutations in the HFE gene. Juvenile hemochromatosis...
Sprague-Dawley rats were given Jectofer injections to obtain iron overload in rat liver Kupffer and parenchymal cells. The release of iron was studied on the light and electron microscopical level by bleeding of the iron loaded animals and comparing the results with non bled controls. During the...
Objective To investigate the anemia and iron overload in patients with β-thalassemia major(TM) in Guangxi, and to provide basic data and reference for clinical treatment aiming at improving the quality of life of the patients. Methods From 2011 to 2017, data of 1 029 TM patients in 923~(...
in the heart the ferritin heavy chain is the dominant subunit. A study in a mouse model of iron overload showed that whileFTH1mRNA levels were constitutively higher in the heart thanFLCmRNA,FLCexpression was more sensitive to increased cardiac iron levels48. Increased expression of FLC in the...
Iron overload is associated with various pathological changes which contribute to metabolic syndrome, many of which have been proposed to occur via damaging tissue through an excessive amount of reactive oxygen species (ROS) production. In this study, we established a model of iron overload in L6...
Results We demonstrated that features associated with T2DM in Leprdb/db mice, such as obesity, steatosis, or IR, reduce the degree of tissue iron overload in Fpnwt/C326S mice, suggesting an ‘iron resistance’ phenotype. Conversely, we observed increased serum iron levels that strongly exceeded...
Iron overload often occurs during blood transfusion and iron supplementation, resulting in the presence of non-transferrin-bound iron (NTBI) in host plasma and damage to multiple organs, but effects on the intestine have rarely been repo... Q Zhang,H Ding,X Yu,... - 《Science China Life ...
Patients with T2* value > 20 ms have normal cardiac function while the prevalence of myocardial dysfunction and arrhythmias increases as a consequence of cardiac iron overload (T2* 10 years. MRI evaluation (1.5T, GE MRI system) included: Left ventricular (LV) function (ejection fraction)- ...
et al. Health-related quality of life, treatment satisfaction, adherence and persistence in β-thalassemia and myelodysplastic syndrome patients with iron overload receiving deferasirox: results from the EPIC clinical trial. Anemia 2012, e297641 (2012). Google Scholar Borgna-Pignatti, C. & Mars...