Wang, Min and their colleagues investigated a mouse stand-in for hemochromatosis, a hereditary disorder in which iron silently accumulates, damaging joints and essential organs like the heart, liver and kidneys. Often the i...
Fillebeen, C., Mitchell, V., Dexter, D., Benaissa, M., Beauvillain, J.C., Spik, G. and Pierce, A. (1999) “Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment”,Mol. Brain. Res.72, 183–194. ArticlePubMedCASGoogle Scholar Foury, ...
within macrophages and in virulence in a mouse model. Together, by demonstrating a critical role for VIT during iron detoxification inT. gondii, we reveal the importance of iron storage in the parasite and provide the first insight into the machinery involved. Similar content being viewed by other...
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In line with the latter idea, Vibrio vulnificus causes lethal septicaemia in a mouse model of severe iron overload (Hamp−/− mice) suggesting that iron overload predisposes to a fatal outcome of otherwise uncommon infections [220]. Importantly, iron overload also negatively affects the ...
Protein extraction and Western blotting were carried out as described using a rabbit Fpn1 antibody (1:400; Eurogentec, Lìege, Belgium), a mouse anti-human TfR1 antibody (1:1000; Invitrogen), a rabbit anti-human ferritin antibody (1:500; Sigma-Aldrich), a rabbit anti HO-1 antibody (1:...
The IRP/IRE system in vivo: insights from mouse models. Front. Pharmacol. 5, 176 (2014). PubMed PubMed Central Google Scholar Volz, K. The functional duality of iron regulatory protein 1. Curr. Opin. Struct. Biol. 18, 106–111 (2008). CAS PubMed PubMed Central Google Scholar ...
Iron load has local effects in AT. In acute iron overload, AT seems to be more sensitive to iron accumulation than liver [39]. In a mouse model where adipocytes were selectively rendered iron deficient by adipocyte-specific deletion of transferrin receptor-1, inguinal and brown AT reduced in...
In our previous work, we demonstrated that iron overload in mouse models and humans with hemochromatosis show an aggravation of atherosclerosis and vessel damage, respectively [5]. Specifically, we found that NTBI in the circulation contributes to atherosclerosis by oxidising low-density lipoproteins ...