Iron is essential for many cellular functions; consequently, dis- turbances of iron homeostasis, leading to either iron deficiency or iron overload, can have significant clinical consequences. Despite the clini
Only approximately 10% of dietary iron is absorbed in physiologically normal persons, and this absorption is regulated in accordance with body iron stores. 2. Iron absorption is downregulated when serum transferrin saturation is high and following high dietary iron intake. 3. In HH, iron absorption...
The first life on the earth is believe to be born in the Fe(II)-rich and O2-low ocean. Ga, giga annum (billion years ago). Refer to text for details. Iron is absorbed in higher animals, including humans, through the duodenum, the first portion of small intestine, immediately after ...
An iron-overload disorder, in which an excessive amount of iron is absorbed from the diet. The iron accumulates in various organs, including the liver, pancreas and heart, which can lead to severe organ damage. ENDOSOMAL COMPARTMENT A system of organelles that carry materials that have been in...
Iron from meat, poultry and fish (heme iron) is absorbed two to three times more efficiently than iron from plants (non-heme iron) is absorbed. The amount of iron absorbed in the body also depends on the other types of foods eaten at the same meal. Foods like meat or fish that contai...
An average adult has 3–5 g of iron in their body [3], while only 1–2 mg of iron is normally absorbed in the intestinal tract, which would then be available for body-wide circulation [4]. Free iron also exists intracellularly in the labile iron pool (LIP) and leads to the ...
The human body has mechanisms in place to both absorb and excrete iron, ensuring that its levels remain balanced. Iron is absorbed primarily in the duodenum and upper jejunum of the small intestine, with the rate of absorption being influenced by the body’s current iron stores and its demand...
In general, iron present in foods in the form of heme, the so-called heme iron, is much better absorbed into the body than non-heme iron. Heme iron is only found in animal foods. For this reason, animal foods are considered a better source of iron than plant foods. The iron present...
The released iron is mainly used for the production of new red cells in the bone marrow. Dietary iron is absorbed in the duodenum and proximal jejunum. On average, 1 to 2 mg iron is absorbed every day by the enterocytes and transferred into the serum. Under normal conditions, this amount...
Ferritin iron is absorbed as the intact, protein-coated mineral, by an endocytic process14 analogous to transferrin (Figure 2(b)), but the mechanistic details are many fewer. Recently, a receptor for endogenous, tissue ferritin, TIM-2, was identified in kidney and liver.15 Whether intestinal ...