Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemodialysis (CHD). Methods To this end, we conside...
Serum gallium levels of 0.115 and 0.569 μg/ml have been achieved following a single oral dose of 100–500 mg gallium maltolate; this is comparable to steady-state levels achieved with gallium nitrate administered by continuous intravenous infusion [110]. The majority of gallium appearing in the...
Iron deficiency is the commonest nutritional deficiency disorder prevalent worldwide. It is the main cause of anemia during pregnancy and lactation among women and infancy and preschool age in children. In the developing countries, the prevalence is usua
Iron poisoning is a well-respected historically significant toxicologic problem. In the pediatric population, iron has been regarded as the most fatal of all toxic exposures [1]. Fortunately because of regulations on packaging in the USA and other countries, serious poisonings have declined [2]. ...
Patients received ferric carboxymaltose (FCM), a recent formulation of intravenous iron, allowing higher doses and rapid infusion times. Following FCM infusion as a single dose of 15 mg/kg up to 1000 mg over 15–20 min, 64% of patients with IDA had resolution of anemia, with 81% ...
Both IVFC and the placebo were administered intravenously via a black infusion set, and the procedure was performed behind a screen in order to assure blinding of the patient. This was administered by a person who was not involved in data collection or data entering. 2.5. Endpoints The ...
Implantation under kidney capsules and intraportal infusion into diabetic mice models showed restoration of normoglycemia. The ability of the transplanted islets to secrete insulin was confirmed by performing ex vivo microscopic studies. A complete study on the monitoring of pancreatic islets was ...
This decrease was prevented by infusion of the Fe chelator, desferrioxiamine [171]. Neurodegeneration by 6-OHDA is selective for catecholamine neurons, and it is rapidly oxidized to yield cytotoxic catecholaminergic semiquinones and quinones with production of H2O2 and hydroxyl radicals. Iron-...