Pathological staining of the lungs, kidneys, and spleen was performed after iron stent degradation. Fig. S2a shows that no abnormalities were detected in the histomorphology of vital organs. Prussian blue staining was performed on the kidneys, lungs, and liver to detect iron ion accumulation in ...
For patients weighing 50 kg or more: Administer 1,000 mg of Monoferric by intravenous infusion over at least 20 minutes as a single dose. Repeat dose if iron deficiency anemia reoccurs. For patients weighing less than 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intraven...
Hepcidin is produced at a high rate (∼10 mg/d at baseline) (28) and is rapidly cleared from the circulation by the kidneys, with a half-life of several minutes (29). Thus, altering the hepcidin production rate can rapidly change its circulating concentrations, and consequently the flow ...
Weak expression of TfR, DMT1, FPN, and hepcidin mRNA was observed in the kidneys of control rats. In contrast, after 7 days of angiotensin II infusion by osmotic minipump, the expression of these mRNAs was more widely distributed. Staining of serial sections revealed that some, but not ...
Arrows on A and B (lower power) Figure 2. In renal branching morphogenesis, glomeruli develop in succes- sive generations that arcade out toward the renal capsule. Kidneys in longi- tudinal sections at ϫ2.5 (A), showing perinatal nephrogenesis P(-2), P1, P8, and P20 in untreated ...
Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS). However, IONPs may damage neural tissue via free iron accumulation, protein aggregation, and oxidative stress. Neuroprotective effects of quercetin (QC) have...
The kidneys of DFX-treated mice had no visible hyphae and there was an effective neutrophil inflammatory reaction, whereas kidneys of placebo-treated mice had extensive filamentous fungi and manifested a poor or complete absence of a neutrophil inflammatory response.134 In another experiment, mice ...
The duration of the infusion did not influence the adverse effects profile. Intramuscular iron Iron compounds for intramuscular administration are iron sorbitol-citric acid complex (iron sorbitex), iron dextran, iron glycerin-citric acid complex, and iron polyisomaltose. The work on these ...
A two electron reduction occurs on the ketone on carbon 13 to form doxorubicinol, a secondary alcohol metabolite (Joerger et al., 2005; Skarka et al., 2011). The liver plays the largest role in this metabolism, along with the kidneys and the GIT (Joerger et al., 2005; Kassner et ...
organs, while efficiently capturing plasma iron and being cleared exclusively by the kidneys.bSynthetic scheme of renal clearable DFO-NPs.mrepresents the number of DFO moieties conjugated on EPL. NIR fluorescent ZW800-1C (green color) was conjugated to track the fate of nanochelators in the ...