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FCM (Ferric Carboxy Maltose) is a new parenteral iron drug that is the first of its kind to be approved by the United States FDA for quick and high-dose iron replenishment. It is used as an iron replacement drug for the treatment of iron deficiency anemia (IDA) in adult patients with ...
MetabolismAfter intravenous infusion, iron dextran is taken up by the cells of the reticuloendothelial cells, particularly in the liver and spleen. The reticuloendothelial cells gradually separate iron from the iron-dextran complex. Most absorbed iron is bound to transferrin and transported to the ...
Data from studies in adults show that IV iron is contraindicated in the course of infections, in the first trimester of pregnancy, and in patients with a history of iron or of another significant (i.e., anaphylactic) drug allergy. Immediate side effects of an IV iron infusion can be nause...
This analog of dimercaprol, among the least toxic of the chelators, may be given parenterally in some countries (China), but mostly in oral form only (Europe and USA), in doses of 30 mg/kg/day for 5–7 days, followed by 20 mg/kg/day for 1–3 weeks. The drug is 95% plasma...
Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Venofer is manufactured under license from Vifor (International) Inc., Switzerland...
Thus, doxorubicin-induced release of free radicals may cause oxidative stress, resulting in DNA damage and cell death [3]. A study using gas chromatography/mass spectrometry has shown that after 72 to 96 h of slow intravenous infusion of doxorubicin with a steady level of 0.1 μM in the ...
Blood loss: total iron dose in mg = blood loss (mL) x HCT Interactions Interaction Checker Enter a drug name to check for any interactions. + iron dextran complex All Interactions Sort By: Contraindicated (0) Serious (15) baloxavir marboxil benazepril captopril demeclocycline doxycycline el...
ANIMAL STUDIES: Rats treated with iron; dextran; by intramuscular injection at a total dose of 100 mg of iron;/kg in divided doses over a 12-week period exhibited no drug-related abnormalities. At ten times this dose, 1000 mg of iron;/kg, treated rats had enlarged livers and spleens ...
It is important to clarify that if a need exists to use the drug at a later date, then the procedure must be repeated. Conclusion This report reflects the utility of using a desensitization protocol in patients with hypersensitivity to iron when it has not been possible to recover a normal ...