Thus, doxorubicin-induced release of free radicals may cause oxidative stress, resulting in DNA damage and cell death [3]. A study using gas chromatography/mass spectrometry has shown that after 72 to 96 h of slow intravenous infusion of doxorubicin with a steady level of 0.1 μM in the ...
Iron-dextran and certain other polysaccharide iron complexes have induced local sarcomas in mice, rats, rabbits, and hamsters following subcutaneous or intramuscular injection in large doses, along with evidence of a dose-response relationship (Haddow and Horning, 1960; Richmond, 1959; Roe and Carte...
Staphylococcus aureusis the cause of a spectrum of diseases in humans and animals. The molecular basis of this pathogenicity lies in the expression of a variety of virulence factors, including proteins that mediate adherence to the host plasma and extracellular matrix proteins. In this study, we ...
A factor present in lysed erythrocytes was found to greatly reduce the 50% lethal dose of for . Similar effects were observed with ferric and manganous . grown in brain heart infusion containing lysed erythrocyte factor appeared to produce a which was either inapparent or absent when the ...
Therefore, the loss of ferritin binding is correlated with demyelination, accompanying multiple sclerosis.48 Reactive Oxygen Species participate in the pathogenesis of allergic encephalomyelitis, whereas the infusion of apoferritin in experimental animals may induce a remission status.49 Thyroid hormone up...
When using the iron-dextran powder for producing injection or infusion liquids, the powder is re-dissolved in an aqueous medium, the pH is checked and, if necessary, adjusted, and the solution is filled into ampoules or vials after being sterilized by filtration. Alternatively, the sterilization...
Serum gallium levels of 0.115 and 0.569 μg/ml have been achieved following a single oral dose of 100–500 mg gallium maltolate; this is comparable to steady-state levels achieved with gallium nitrate administered by continuous intravenous infusion [110]. The majority of gallium appearing in the...
In addition, we revealed that DHA might exert its antiepileptic effects by modulating iron homeostasis in the brain and finally inhibitingferroptosis. This work provides a reliable chemical tool for assessing the status of ferrous iron in the living epileptic mouse brain and may aid the rapid ...
The retarding effect these chelators have on microbial growth suggests that they could have a potential application as a co-active alongside antibiotics in the fight against infections. Graphical abstract Novel hexadentate chelators based on 1-hydroxy-2(1H)-pyridinone and a triaza macrocyclic core ...
Iron oxide nanoparticle (IONP)-based technologies are catalyzing rapid developments in nanotechnology. Due to technological importance, extensive research has been carried out on the development of various synthetic routes to yield IONPs with desired properties [1]. Among IONPs, mainly Fe3O4 and γ...