Standard oral iron therapy should not be dismissed in heart failure patients with anemia and depleted iron stores (ferritin < 30 ng/mL) as, contrary to intravenous iron trials, these patients were not included in a trial resulting in neglectable effect of oral iron on exercise capacity....
To date, 3 clinical trials have shown symptomatic benefit from the use of intravenous (IV) iron in patients with heart failure (HF) with low serum iron. This has led to recommendations in support of the use of IV iron in this population. However, the systemic and cellular mechanisms of ir...
IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia. Int J Cardiol. 2013;168(4):3439-3442. doi:10.1016/j.ijcard.2013.04.181 PubMedGoogle ScholarCrossref 52. Beguin Y, Maertens J, De Prijck B, et al. Darbepoetin...
Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers. J Intern Med. 1995;237161- 168Google ScholarCrossref 108. Matthews AJVercellotti GMMenchaca HJ et al. Iron and atherosclerosis: inhibition by the iron ...
Trials investigating intravenous iron in heart failure, including the ferric carboxymaltose formulation approved today as well as ferric derisomaltose, which was tested in the recentIRONMANtrial, have delivered somewhat mixed results. Complications posed by the COVID-19 lockdowns have been widely blamed...
He eventually perfected the flight power after much trial and error, taking the silver Mark II suit for its first test flight, despite J.A.R.V.I.S.' warnings that there had not been enough tests. He soared high in the sky over the city and shouted in delight at his success. ...
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in t
Rand plunged his hands into the now unguarded brazier containing Shou-Lao's molten heart when his hands had shone with a quasi-mystical force and he finally earned the title Iron Fist.[14] With his trial succeeded, Rand had gained his power and the Mark of Shou-Lao onto his chest before...
This randomized clinical trial investigates the efficacy of oral iron supplementation for improvement of exercise capacity in adult patients with heart
hospitalization for heart failure, or death. After a median of 2.1 years of follow-up, participants randomized to the proactive approach had higher serum ferritin and transferrin concentrations, more rapid increases in hemoglobin from baseline despite lower cumulative doses of erythropoiesis-stimulating ...