Immune cellsTargeted therapyCompared with the traditional forms of cell death鈥攁poptosis, necrosis and autophagy, ferroptosis is a novel form of iron-dependent programmed cell death forms which is different from the above traditional forms of cell death. Brent R Stockwell, a Professor of Columbia ...
Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib 本文选自International Journal of Cancer,2013年,划时代发现索拉菲尼诱导肝癌铁死亡。 文章篇幅不多,大家当复习历史了。 摘要:多激酶抑制剂索拉非尼是目前治疗晚期肝细胞癌(HCC)的参考药物。在我们的报告中,我们检测了索拉非尼对肝癌细...
that ironomycin, derivatives of salinomycin, exhibited more potent and selective therapeutic activity against breast cancer stem cells by accumulating and sequestering iron in lysosome, followed by an iron-mediated lysosomal production of reactive oxygen species and an iron-dependent cell death. These ...
我们计算了每种抑制剂(按10点4倍稀释系列测试)对致死剂量的erastin(Me<0,死亡致敏;Me=0,无效;Me>0,死亡钝化)处理的细胞归一化活性的调节作用(Me<0,死亡致敏;Me=0,无效;Me>0,死亡钝化)。结果值以无人监督的方式分层聚类,并显示为热图。使用这种方法,我们观察到,erastin诱导的死亡并不一致地受到caspase、组织...
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012; 149: 1060-1072.Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. 2012. Ferroptosis: an iron-dependent form of nonapop- totic cell death....
Programmed cell death (PCD) is an integral component of both developmental and pathological features of an organism. Recently, ferroptosis, a new form of PCD that is dependent on reactive oxygen species and iron, has been described. As with apoptosis, necroptosis, and autophagy, ferroptosis is ...
Iron is essential for biological systems but can also damage or kill cells, leading to a variety of disease states. A review of mechanisms leading to Fe- and ROS-dependent cell death highlights the vast array of open questions in this complex field. The
Ferroptosis is a newly recognized type of iron-dependent cell death, characterized by iron overload and lipid peroxidation accumulation. In 2003, Dolma et al. [14] first identified the compound erastin, which exhibited selective lethality against cancer cells expressing RAS, but it was noted that ...
Artist’s impression of the destruction of a cell. Cells may be destroyed by ferroptosis, a type of programmed cell death that is dependent on iron. 王福俤当年刚开始涉足硒、锌、铁、锰和铜等金属离子的生物学功能时,他...
Faculty Opinions recommendation of Ferroptosis: an iron-dependent form of nonapoptotic cell death. R. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060-1072; 2012.Dixon, S. J.; Lemberg, K. M.; Lamprecht, M. R.; ... YJ Suzuki 被引量: 0发表: 2012年 Replicat...