Aim: Studies imply that significance of iron deficiency (ID) and iron deficiency anaemia (IDA) for pregnancy outcomes is especially highlighted in the early pregnancy. Prevalence around the world varies widely, however, no data is available up to date for Croatia or neighbouring countries. ...
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with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that ma...
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. Nucleic Acids Res. 39, 4373–4386 (2011). Article CAS Google Scholar Sato, T. et al. mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating ...
Objective Ten percent of adults presenting with iron deficiency anaemia (IDA) have underlying cancer. This analysis – the Iron Deficiency as an Indicator Of Malignancy (IDIOM) study – was undertaken to assess whether five simple clinical parameters can usefully predict the likelihood of gastrointestin...
Iron deficiency without anaemia implies that haemoglobin synthesis is impaired, but that haemoglobin concentration has not fallen sufficiently to meet the definition of anaemia. It is usually recognised on the basis of criteria other than haemoglobin concentration: serum ferritin (<l0 μg/l), ...
1). Iron deficiency results when the absorptive capacity of the small intestine (which increases to a maximum of two- to fourfold above normal) is exceeded by iron loss over a prolonged period of time. Sign in to download full-size image Fig. 1. Gastrointestinal blood loss and iron balance...
During the mean follow-up period of 4.0 years, adjusted relative rate (95% confidence interval) for all-cause mortality in three abnormal iron groups were increased compared to the reference: functional iron deficiency [1.21 (1.17, 1.25)], low iron [1.10 (1.07, 1.14)], and high iron [...
Malaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID1. To test the hypothesis that malaria might cause ID, we used sickle cell trait (HbAS,rs334), a ...
Iron metabolism is a tightly regulated physiological process that has relatively low redundancy, and its deregulation often leads to iron deficiency or iron overload. Iron deficiency and iron overload are historically associated with erythroid disorders; however, deregulated iron metabolism is also implica...