Iron deficiency causes anaemia and growth arrest, whereas iron overload is toxic because of its redox reactivity, which promotes oxidative stress [3]. Hereditary haemochromatosis (HH) is the most common genetic iron overload disorder among Caucasians; it occurs in approximately one in 200–250 ...
Iron Deficiency Anaemia and Iron Overload MarkWorwood, ...Barbara J.Bain, inDacie and Lewis Practical Haematology (Twelfth Edition), 2017 Regulation of iron metabolism The expression of a number ofiron proteinsinvolved in both transport and storage is largely controlled post- transcriptionally by ir...
A naturally occurring mutation at Gly185 in TM4 (Gly185Arg) is associated with severe iron deficiency and microcytic anemia of themk mouse2 and of the Belgraderat.3 When expressed in the yeast smf1/smf2mutant, the Gly185Arg variant of Nramp2 can be expressed in the membrane fraction of ...