We identified cellular conditions in which the biosynthesis of heme, the iron-containing cofactor present in hemoglobin and other enzymes, may be directly influenced by cellular Fe-S cluster assembly processes. This interdependence of the heme biosynthesis and Fe-S cluster assembly pathways relied on ...
In the root nodules of legumes, hemoglobin catalyzes the fixation of atmospheric N 2 by symbiotic bacteria. Heme is also the active site of peroxidases that protect cells from oxidative injury by reducing peroxides to water. In plants, iron-containing ferredoxins are essential for an early step ...
and less iron deposition at the transition zone, although clusters of iron were found at the border of the fibrotic region of the infarct (Figs.1eand4b, c), indicating an active immune response with newly recruited macrophages (Fig.4b) and iron containing MHC class II antigen-presenting ...
E. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. Proc. Natl Acad. Sci. USA 110, 8662–8667 (2013). CAS PubMed Google Scholar Sehlin, D. et al. Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's ...
Iron metabolism consists of the absorption of dietary iron from the gastrointestinal tract, transport in the blood, storage in the liver and macrophages, and utilization in the cells requiring synthesis of iron-containing proteins (e.g., hemoglobin in erythroblasts). Iron deficiency causes anemia ...
A specific region of lactoferrin, near the N terminus of the molecule, is strongly basic and is reported to mediate some of lactoferrin’santimicrobial activity. “Lactoferricins,” small peptides containing this basic region, produced by proteolytic cleavage reportedly bind to lipopolysaccharide, leadi...
The cells were lysed in RIPA buffer containing a protease inhibitor cocktail for 15 min on ice, followed by centrifugation at 12,000 g. The total protein concentration was determined using the BCA protein assay kit (Beyotime, China). A total of 20 micrograms of protein was loaded onto a SDS...
Coulson enters the building anyway and informs Tony that the Initiative is now active and they need him to come in, handing Stark several holographic screens containing information about Captain America, Thor, Bruce Banner, and Loki. Iron Man meets Captain America....
Iron deficiencies are the most common nonenteric syndromes observed in patients with inflammatory bowel disease, but little is known about their impacts on immune tolerance. Here we show that homeostasis of regulatory T cells in the intestine was depende
(e.g., chelating agents) or anhydrous formulation20, which can reduce fluoride bioavailability. We unexpectedly found that SnF2was stable in aqueous solutions containing Fer without additives. To further investigate the stability of SnF2in the presence of Fer, SnF2(250 ppm of F) was mixed ...