To date, dexrazoxane, a potent iron chelator, is the only cardioprotective drug clinically approved for the prophilaxis of anthracycline-induced cardiac damage. Its activity as a chelator enables dexrazoxane to either bind free iron or remove iron from the DOXO–iron complex thus preventing oxygen ...
DOSAGE AND ADMINISTRATION: Administrated by deep intramuscular injection. Dosages per time for piglets are100-200mg, for calves 200-600mg, for baby dogs are 20-200mg. Precaution: 1. When the serious impairment of hepatic and renal function shouldn’t be use. ...
275 Deferiprone, a neutral molecule, forms a neutral 3:1 chelator:ferric iron complex at pH 7.4. The drug may mobilize iron from ferritin, hemosiderin, lactoferrin, and diferric transferrin.276, 277 Animal studies have reported variable efficacy in rodents and rabbits,277, 278, 279, 280, 281...
The psychological aspects of steroid use are also complex. Dan Duchaine put it perfectly when he made this statement: "Once you use steroids, your whole outlook on your sport changes, usually irrevocably. You will find a pessimism, a cynicism about the sport and its athletes that you ...
The Ames test for mutagenicity did not demonstrate any evidence of cellular effect of AMI-25 up to its highest dosage concentration. Histopathology did reveal iron deposits in hepatic and reticuloendothelial tissue without any evidence of cell damage. Although iron toxicity remains a concern, ...