Some compounds, although not primarily designed as supportive drugs in chemotherapy, are promising candidates for clinical use. The ability of HI-6 oxime to relieve the side effects of irinotecan was recently determined in vitro. In this animal study, we investigated the efficacy of HI-6 in ...
and other problems. Tell your doctor if you have or have ever had a bowel obstruction (blockage in your intestine). Tell your doctor and pharmacist if you are taking any of the following medications: other chemotherapy medications forcancer; diuretics ('water pills'); or laxatives such as bis...
Camptosar Injection (irinotecan hydrochloride) is anantineoplastic(anticancer) medication used to treat cancers of thecolonandrectum. Camptosar Injection is usually given with other cancer medicines in combinationchemotherapy. Camptosar Injection is available ingenericform. What Are Side Effects of Campto...
Chemotherapy and Anti-Epileptic Drug Interactions Karen L.Fink, inHandbook of Brain Tumor Chemotherapy, 2006 Irinotecan Irinotecanis a striking example of the potential for ineffective chemotherapy in patients taking EIAEDs, and of the need for dose adjustments in these patients. Whenirinotecanwas given...
Gastrointestinal dysfunction is a common side-effect of chemotherapy leading to dose reductions and treatment delays. These side-effects may persist up to 10 years post-treatment. A topoisomerase I inhibitor, irinotecan (IRI), commonly used for the treatment of colorectal cancer, is associated with ...
(PFST), in addition to the potential antitumoral effects of a first- or second-line therapy we studied the therapeutic efficacy of a third- or fourth-line chemotherapy with irinotecan alone, or in combination with oxaliplatin and high dose 5-FU/FA respectively, in a pilot study in 17 ...
Side effects can include: fatigue, acute cholinergic syndrome (Increased sweating, production of saliva, stomach cramps and diarrhoea) which can be drug controlled, diarrhoea, nausea and vomiting. Approved by the Medical Board. Click Here Go to:10 ways to improve your chemotherapy success and reduc...
If IPD is diagnosed, irinotecan and other chemotherapy should be discontinued and appropriate treatment instituted as needed [see Adverse Reactions (6.1)]. 5.7 Toxicity of the 5 Day Regimen Outside of a well-designed clinical study, Irinotecan Hydrochloride Injection, USP should not be used in ...
Patients with risk factors should be closely monitored for respiratory symptoms before and during therapy; new or progressive, dyspnea, cough, and fever should prompt interruption of chemotherapy, pending diagnostic evaluation If IPD is diagnosed, this drug and other chemotherapy should be discontinued ...
For patients with advanced gastric cancer (AGC), second-line chemotherapy regimen remains controversial. The efficacy and safety of irinotecan-containing doublet treatment and irinotecan monotherapy were compared in this systematic analysis. Methods A search was conducted on EMBASE and Medline databases. ...